Infectious Diseases – Scholarship and Research

Research Activities

Research activities are a critical component of the Pediatric Infectious Diseases (ID) Training Program. All ID subspecialty fellows will devote a minimum of 18 months to research activities.

Understanding the basic science underlying pediatric infectious diseases and related disciplines is encouraged throughout the fellowship. This is accomplished through trainee presentations at research seminars, review at Journal Club of basic research articles and attendance at basic research seminars in the Division of Pediatric Infectious Diseases and Immunology, the Department of Pediatrics, and the Department of Microbiology and Immunology.

Scholarly Activities

Scholarship is an important component of pediatric ID faculty and subspecialty resident activities and duties. The Pediatric Division of Infectious Diseases is dedicated to maintaining an environment of inquiry and an active research component is an integral part of the pediatric ID training program. Scholarship is defined as one of the following:

  • The scholarship of discovery, as evidenced by peer-reviewed funding or publication of original research in peer-reviewed journals.
  • The scholarship of dissemination, as evidenced by review articles or chapters in textbooks.
  • The scholarship of application, as evidenced by the publication or presentation at local, regional, or national professional and scientific society meetings, for example, case reports or clinical series.
  • Active participation of the teaching staff in clinical discussions, rounds, journal club, and research conferences in a manner that promotes a spirit of inquiry and scholarship; offering of guidance and technical support, e.g., research design, statistical analysis, for pediatric ID subspecialty residents (fellows) involved in research; and provision of support for pediatric ID subspecialty resident participation as appropriate in scholarly activities.

Opportunities for Research

All trainees participate in a major clinical, epidemiologic, and/or laboratory research project during their fellowship. After beginning the program, all fellows will identify a faculty mentor under whose guidance they will carry out their research project. Research faculty can be drawn from division members in the Division of Infectious Diseases and Immunology, but also from Departments of Virology, Microbiology and Immunology, and Pharmacy at the University of Connecticut campuses in Farmington and Storrs, and from the Center for Anti-Infective Research at Hartford Hospital.

Fellows will be expected to partake in one or two additional smaller research efforts that would typically involve a quality-improvement aspect of systems-based practice or practice-based learning and improvement. A specific project will be identified in the area of antimicrobial stewardship with an expectation of submission as an abstract, the second will be in an area of the fellow’s choosing.

Recent Publications

Tutolo JW, Staples JE, Sosa L, Bennett N. Notes from the Field: Powassan Virus Disease in an Infant - Connecticut, 2016. MMWR Morb Mortal Wkly Rep. 2017 Apr 21;66(15):408-409.

Hawley KL, Cruz AR, Benjamin SJ, La Vake CJ, Cervantes JL, LeDoyt M, Ramirez LG, Mandich D, Fiel-Gan M, Caimano MJ, Radolf JD, Salazar JC  IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages Front Immunol. 2017 Oct 5;8:1227.

Flores G, Salazar JC Immigrant Latino Children and the Limits of Questionnaires in Capturing Adverse Childhood Events. Pediatrics. 2017 Nov;140(5).

Held MR, Kotler H, Sneller H, Sullivan CB. Lemierre's Syndrome Presenting as Multifocal Pyomyositis in a Young Child. Pediatr Infect Dis J. 2017 Sep 5.

Sigurjonsdottir VK, Feder HM Jr, Wormser GP. Anaplasmosis in pediatric patients: Case report and review. Diagn Microbiol Infect Dis. 2017 Nov;89(3):230-234.

Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Sci Rep. 2017 Sep 7;7(1):10882.

Vivar S, Girotto JE, Murray TS. A Dual Case of Peritonitis and Central Nervous System Infection Caused by Nutritionally Variant Streptococcal Species. Case Rep Infect Dis. 2017;2017:6012964.

Dassner AM, Girotto JE. Evaluation of a Second-Sign Process for Antimicrobial Prior Authorization. J Pediatric Infect Dis Soc. 2017 Apr 12.

Nichols K, Stoffella S, Meyers R, Girotto J; Advocacy Committee for the Pediatric Pharmacy Advocacy Group. Pediatric Antimicrobial Stewardship Programs. J Pediatr Pharmacol Ther. 2017 Jan-Feb;22(1):77-80.

Nichols K, Girotto J, Steele AM, Stoffella S; Advocacy Committee for the Pediatric Pharmacy Advocacy Group. Duty to Advocate: Human Papillomavirus Vaccination. J Pediatr Pharmacol Ther. 2017 Jan-Feb;22(1):74-76.

Dassner AM, Sutherland C, Girotto J, Nicolau DP. In vitro Activity of Ceftolozane/Tazobactam Alone or with an Aminoglycoside Against Multi-Drug-Resistant Pseudomonas aeruginosa from Pediatric Cystic Fibrosis Patients. Infect Dis Ther. 2017 Mar;6(1):129-136.

Dassner AM, Nicolau DP, Girotto JE. Management of Pneumonia in the Pediatric Critical Care Unit: An Area for Antimicrobial Stewardship. Curr Pediatr Rev. 2017;13(1):49-66.

Courter JD, Nichols KR, Kazazian C, Girotto JE. Pharmacodynamically Guided Levofloxacin Dosing for Pediatric Community-Acquired Pneumonia. J Pediatric Infect Dis Soc. 2017 Jun 1;6(2):118-122.

Puthenveetil R, Kumar S, Caimano MJ, Dey A, Anand A, Vinogradova O, Radolf JD. The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola. Sci Rep. 2017 Oct 16;7(1):13260.

Nally JE, Grassmann AA, Planchon S, Sergeant K, Renaut J, Seshu J, McBride AJ, Caimano MJ. Pathogenic Leptospires Modulate Protein Expression and Post-translational Modifications in Response to Mammalian Host Signals. Front Cell Infect Microbiol. 2017 Aug 9;7:362.

Grove AP, Liveris D, Iyer R, Petzke M, Rudman J, Caimano MJ, Radolf JD, Schwartz I. Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete. MBio. 2017 Aug 22;8(4). pii: e01204-17.

Fitzstevens JL, Smith KC, Hagadorn JI, Caimano MJ, Matson AP, Brownell EA. Systematic Review of the Human Milk Microbiota. Nutr Clin Pract. 2017 Jun;32(3):354-364.