{"id":1541,"date":"2025-04-02T17:49:35","date_gmt":"2025-04-02T21:49:35","guid":{"rendered":"https:\/\/health.uconn.edu\/germline-stem-cells\/?page_id=1541"},"modified":"2025-04-14T14:31:43","modified_gmt":"2025-04-14T18:31:43","slug":"research","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/germline-stem-cells\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

Our Research Overview<\/h3>\t\t\t

Our lab investigates the mechanisms of stem cell regulation and how dysregulation may lead to disease states. Specifically, we utilize the powerful\u00a0Drosophila Melanogaster\u00a0<\/em>as our model system, due to its simple anatomy. This in conjunction with abundant genetic and genomic tools has proven to be well suited to study unrecognized regulatory mechanisms. We combine advanced imaging techniques, genetics, and multi-omics approaches to study germline stem cells (GSCs), factors that may play a role in cell fates, and chromatin architecture within the cells of normal tissues and diseased tissues. Our research is focused on a few areas, such as chromatin state dynamics, the roles of nuclear non-coding RNAs in stem cell function and changes in extracellular matrix during tissue regeneration. Ultimately, we aim to deepen our knowledge of disease progression and contribute to developing new approaches to disease therapies and prevention.<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div>

Why is it important to understand how stem cells are regulated?<\/h3>\t\t\t
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