{"id":9,"date":"2019-09-10T15:25:52","date_gmt":"2019-09-10T19:25:52","guid":{"rendered":"https:\/\/health.uconn.edu\/bae-lab\/?page_id=9"},"modified":"2025-01-03T11:13:05","modified_gmt":"2025-01-03T16:13:05","slug":"research","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/doolittle-lab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div id=\"pl-9\"  class=\"panel-layout\" ><div id=\"pg-9-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-9-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-9-0-0-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"panel-widget-style panel-widget-style-for-9-0-0-0\" ><img loading=\"lazy\" decoding=\"async\" width=\"4400\" height=\"1100\" alt=\"3 panels of scientific data\" class=\"attachment-full\" style=\"max-width: 100%;\" srcset=\"https:\/\/b342708.smushcdn.com\/342708\/wp-content\/uploads\/sites\/300\/2024\/10\/Picture2.png?lossy=0&amp;strip=1&amp;webp=1 4400w, https:\/\/b342708.smushcdn.com\/342708\/wp-content\/uploads\/sites\/300\/2024\/10\/Picture2-300x75.png?lossy=0&amp;strip=1&amp;webp=1 300w, https:\/\/b342708.smushcdn.com\/342708\/wp-content\/uploads\/sites\/300\/2024\/10\/Picture2-1024x256.png?lossy=0&amp;strip=1&amp;webp=1 1024w, https:\/\/b342708.smushcdn.com\/342708\/wp-content\/uploads\/sites\/300\/2024\/10\/Picture2-768x192.png?lossy=0&amp;strip=1&amp;webp=1 768w, https:\/\/b342708.smushcdn.com\/342708\/wp-content\/uploads\/sites\/300\/2024\/10\/Picture2-1536x384.png?lossy=0&amp;strip=1&amp;webp=1 1536w, https:\/\/b342708.smushcdn.com\/342708\/wp-content\/uploads\/sites\/300\/2024\/10\/Picture2-2048x512.png?lossy=0&amp;strip=1&amp;webp=1 2048w\" sizes=\"(max-width: 4400px) 100vw, 4400px\" src=\"https:\/\/health.uconn.edu\/doolittle-lab\/wp-content\/uploads\/sites\/300\/2024\/10\/Picture2.png\" \/><\/div><\/div><\/div><\/div><div id=\"pg-9-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-9-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-9-1-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><p>The main focus of the Doolittle Lab is to study the development and intercellular signaling of senescent cells in the bone microenvironment. Cellular senescence is a hallmark of aging defined by a lack of proliferation paired with an inflammatory phenotype. Senescent cells accumulate during skeletal aging and contribute to age-related deterioration in bone. However, besides the negative effects on the physical tissue, much remains unknown surrounding the intercellular signaling of skeletal senescent cells. This is particularly important as a majority of the body\u2019s blood cells arise from stem cells within the bone marrow, which are likely directly exposed to aged senescent cells in the skeleton. It is also unclear if the persistence of senescent skeletal cells is due to their ability to evade clearance by the body\u2019s immune response, similar to cancer cells. Therefore, our lab is investigating these molecular interactions between senescent skeletal cells and immune cells through the application of transcriptomics, proteomics, and live-cell imaging.<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The main focus of the Doolittle Lab is to study the development and intercellular signaling of senescent cells in the bone microenvironment. Cellular senescence is a hallmark of aging defined by a lack of proliferation paired with an inflammatory phenotype. Senescent cells accumulate during skeletal aging and contribute to age-related deterioration in bone. However, besides [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-01 03:40:24","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/pages\/9"}],"collection":[{"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":32,"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":224,"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/pages\/9\/revisions\/224"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}