{"id":18,"date":"2019-09-10T15:40:01","date_gmt":"2019-09-10T19:40:01","guid":{"rendered":"https:\/\/health.uconn.edu\/bae-lab\/?page_id=18"},"modified":"2026-01-29T12:00:02","modified_gmt":"2026-01-29T17:00:02","slug":"publications","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/doolittle-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
\"Google<\/a><\/div><\/div>
\"PubMed<\/a><\/div><\/div>
<\/div><\/div>

2026<\/h2>\n

Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes<\/a>
\nDoolittle ML*<\/strong>, Froemming MN, Rowsey JL, Ruan M, Sapra L, Farr JN, Monroe DG, Khosla S*.\u00a0Journal of Clinical Investigation<\/em>. 2026 Jan.\u00a0*Corresponding Authors<\/strong><\/em><\/span><\/p>\n

2025<\/h2>\n

Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow<\/a>
\nZhang X#<\/sup>,\u00a0<\/span>Doolittle ML#<\/sup><\/span><\/b>, Fan T, Tripathi U, Ng YE, Jiang X, Passos JF, Jurk D, Monroe DG, Tchkonia T, Kirkland JL, Robbins PD, Khosla S, LeBrasseur NK.\u00a0Obesity<\/em>. 2025 Dec. #<\/sup>First Authors<\/strong><\/em>.<\/span><\/p>\n

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues<\/a>
\nSaul D, Jurk D,\u00a0Doolittle ML<\/strong>, Kosinsky RL, Han Y, Zhang X, Franco AC, Kim SY, Wyles SP, Prakash YS, Monroe DG, Ferrucci L, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Khosla S, Passos JF. EMBO Journal<\/em>. 2025 Oct.<\/span><\/p>\n

Global but not myeloid lineage-directed Girk3 deletion increases bone mass in female mice<\/a>
\nWeaver SR, Doolittle ML<\/strong>, Durdan MM, Narum AK, Weivoda MM, Alhamad DW, McGee-Lawrence ME, Khosla S, Taylor EL, Bradley EQ, Marron Fernandez de Velasco E, Wickman K, Westendorf JJ.\u00a0JBMR Plus. <\/em>2025 Aug.<\/p>\n

2024<\/h2>\n

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial<\/a>
\nFarr JN, Atkinson EJ, Achenbach SJ, Volkman TL, Tweed AJ, Vos SJ, Ruan M, Sfeir J, Drake MT, Saul D, Doolittle ML<\/strong>, Bancos I, Yu K, Tchkonia T, LeBrasseur NK, Kirkland JL, Monroe DG, Khosla S. Nature Medicine<\/em>. 2024 Sep.<\/p>\n

SenNet recommendations for detecting senescent cells in different tissues<\/a>
\nSuryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L,\u00a0Doolittle ML<\/strong>, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. Nature Reviews Molecular Cell Biology<\/em>. 2024 Jun.<\/p>\n

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair<\/a>
\nSaul D#<\/sup>, Doolittle ML<\/strong>#,*<\/sup>, Rowsey JL, Froemming MN, Kosinsky RL, Vos SJ, Ruan M, LeBrasseur NK, Chandra A, Pignolo RJ, Passos JF, Farr JN, Monroe DG, Khosla S*<\/sup>. Journal of Clinical Investigation. <\/em>2024 May. #<\/sup>First authors. *Corresponding authors<\/em><\/strong><\/p>\n

Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages<\/a>
\nZhang X, Ng YE, Chini LCS, Heeren AA, White TA, Li H, Huang H, Doolittle ML<\/strong>, Khosla S, LeBrasseur NK.\u00a0Aging Cell<\/em>. 2024 Mar.<\/p>\n

2023<\/h2>\n

Influences of Aged Bone Marrow Macrophages on Skeletal Health and Senescence<\/a>
\nPappert M, Khosla S, Doolittle ML*<\/strong>. Current Osteoporosis Reports<\/em>. 2023 Dec. *Corresponding Author<\/em><\/strong><\/p>\n

Single\u2010Cell Integration of BMD GWAS Results Prioritize Candidate Genes Influencing Age\u2010Related Bone Loss<\/a>
\nDoolittle ML<\/strong>, Khosla S, Saul D.\u00a0JBMR Plus<\/em>. 2023 Oct.<\/p>\n

Modest Effects of Osteoclast\u2010Specific ER\u03b1 Deletion after Skeletal Maturity<\/a>
\nDoolittle ML<\/strong>, Eckhardt BA, Vos SJ, Grain S, Rowsey JL, Ruan M, Saul D, Farr JN, Weivoda MM, Khosla S, Monroe DG.\u00a0JBMR Plus<\/em>. 2023 Oct.<\/p>\n

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton<\/a>
\nDoolittle ML<\/strong>, Saul D, Kaur J, Rowsey JL, Vos SJ, Pavelko KD, Farr JN, Monroe DG, Khosla S.\u00a0Nature Communications<\/em>. 2023 Jul.<\/p>\n

MicroRNA \u00a019a \u00a03p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence<\/a>
\nKaur J, Saul D, Doolittle ML<\/strong>, Farr JN, Khosla S, Monroe DG.\u00a0JBMR Plus<\/em>. 2023 Jun.<\/p>\n

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers<\/a>
\nSamakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML<\/strong>, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell GG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, LeBrasseur NK, Farr JN, Robbins PD, Khosla S.\u00a0Aging<\/em>. 2023 May.<\/p>\n

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis<\/a>
\nFarr JN, Saul D, Doolittle ML<\/strong>, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Ikeno Y, Pignolo RJ, Niedernhofer NJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S.\u00a0Journal of Clinical Investigation<\/em>. 2023 Apr.<\/p>\n

2022<\/h2>\n

Skeletal Effects of Inducible ER\u03b1 Deletion in Osteocytes in Adult Mice<\/a>
\nDoolittle ML<\/strong>, Saul D, Kaur J, Rowsey JL, Eckhardt BA, Vos SJ, Kroupova K, Ruan M, Weivoda MM, Oursler MJ, Farr JN, Monroe DG, Khosla S.\u00a0Journal of Bone and Mineral Research<\/em>. 2022 Sep.<\/p>\n

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues<\/a>
\nSaul D, Kosinsky RL, Atkinson EJ, Doolittle ML<\/strong>, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S.\u00a0Nature Communications<\/em>. 2022 Aug.<\/p>\n

Identification of a suitable endogenous control miRNA in bone aging and senescence<\/a>
\nKaur J, Saul D, Doolittle ML<\/strong>, Rowsey JL, Vos SJ, Farr JN, Khosla S, Monroe DG.\u00a0Gene<\/em>. 2022 Aug.<\/p>\n

Targeted clearance of p21\u2010 but not p16\u2010positive senescent cells prevents radiation\u2010induced osteoporosis and increased marrow adiposity<\/a>
\nChandra A, Lagnado AB, Farr JN, Doolittle ML<\/strong>, Tchkonia T, Kirkland JL, LeBrassseur NK, Robbins PD, Niedernhofer LJ, Ikeno Y, Passos JF, Monroe DG, Pignolo RJ, Khosla S.\u00a0Aging Cell<\/em>. 2022 Apr.<\/p>\n

2021<\/h2>\n

Modulation of fracture healing by the transient accumulation of senescent cells<\/a>
\nSaul D, Monroe DG, Rowsey JL, Kosinsky RL, Vos SJ, Doolittle ML<\/strong>, Farr JN, Khosla S.\u00a0Elife<\/em>.2021 Oct.<\/p>\n

The role of senolytics in osteoporosis and other skeletal pathologies<\/a>
\nDoolittle ML<\/strong>, Monroe DG, Farr JN, Khosla S.\u00a0Mechanisms of Ageing and Development<\/em>. 2021 Oct.<\/p>\n

Neutrophils induce paracrine telomere dysfunction and senescence in ROS\u2010dependent manner<\/a>
\nLagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Visioli MG, Habiballa L, Saretzki G, Evans SA, Salmonowicz, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle ML<\/strong>, von Zglinicki T, Oakley F, Gallage S, Wilson C, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann D, Passos JF.\u00a0EMBO Journal<\/em>. 2021 May.<\/p>\n

Isolation and Culture of Neonatal Mouse Calvarial Osteoblasts<\/a>
\nDoolittle, ML<\/strong>, Ackert-Bicknell, CL, Jonason, JH.\u00a0Methods in Molecular Biology - Skeletal Development and Repair.<\/em> 2021.<\/p>\n

2020<\/h2>\n

Osteocyte Cellular Senescence<\/a>
\nFarr JN, Kaur J, Doolittle ML<\/strong>, Khosla S.\u00a0Current Osteoporosis Reports.<\/em> 2020 Oct.<\/p>\n

Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass<\/a>
\nDoolittle ML#<\/sup><\/strong>, Calabrese GM#<\/sup>, Mesner LD, Maynard RD, Ackert-Bicknell CL*, Farber CR*. PLOS Genetics<\/em>. 2020 Jun. #<\/sup>First authors<\/strong>. *Corresponding authors<\/strong>.<\/em><\/p>\n

Pre-2020<\/h2>\n

Targeting the gut microbiome to treat the osteoarthritis of obesity<\/a>
\nSchott EM, Farnsworth CW, Grier A, Lillis JA, Soniwala S, Dadourian GH, Bell RD, Doolittle ML<\/strong>, Villani DA, Awad H, Ketz JP, Kamal F, Ackert-Bicknell C, Ashton JM, Gill SR, Mooney RA, Zuscik MJ.\u00a0JCI Insight<\/em>. 2018 Apr.<\/p>\n

A Nondestructive, Reproducible Method of Measuring Joint Reaction Force at the Distal Radioulnar Joint<\/a>
\nCanham CD, Schreck MJ, Maqsoodi N, Doolittle ML<\/strong>, Olles M, Elfar JC.\u00a0Journal of Hand Surgery<\/em>. 2015 Jun.<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

2026 Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes Doolittle ML*, Froemming MN, Rowsey JL, Ruan M, Sapra L, Farr JN, Monroe DG, Khosla S*.\u00a0Journal of Clinical Investigation. 2026 Jan.\u00a0*Corresponding Authors 2025 Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow Zhang X#,\u00a0Doolittle ML#, Fan […]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-01 03:40:24","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/pages\/18"}],"collection":[{"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":28,"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":271,"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/pages\/18\/revisions\/271"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/doolittle-lab\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}