Biostatistics Center

The Biostatistics Center is the primary resource for providing biostatistical collaboration and support for biomedical researchers throughout the UConn Health Center. Our goal is to provide support for grant development that leads to externally funded grants, ongoing research collaboration, publications, and translational discoveries. Center staff consult with researchers to identify best analysis strategies, study design, and power analysis. We are available to investigators in all phases of their research within the UConn community.

  • Provide support for grant development that leads to ongoing research collaboration
  • Help developing a statistical plan
  • Power analysis and sample size
  • Complete "Statistical Considerations" section if included on grant
  • Biosketch if listed as a Co-Investigator
  • Consult with researchers on optimal study design
  • Offer classes through the Masters in Clinical and Translational Research program
  • Monthly biostatistics journal club
  • Advising for students and physician-scientists in training
  • Mentoring

James Grady, Dr.P.H.
Director, Biostatistics Center

Chia-Ling Kuo, Ph.D.

Rong Wu, M.S., Ph.D.
Research Associate II


The Biostatistics Center has collaborated on over 100 grant applications and co-authored over 60 peer reviewed manuscripts with UConn faculty. Below is a current list of our co-authored publications.


Townsel C, Keller R, Kuo CL, Campbell WA, Hussain N. Racial/Ethnic Disparities in Morbidity and Mortality for Preterm Neonates Admitted to a Tertiary Neonatal Intensive Care Unit. J Racial Ethn Health Disparities. (August 2018)

Okechukwu Clinton, Ifegwu, Guleid Awale, Ho Man Kan, Komal Rajpura, Edward O’Neill, Chia-Ling Kuo, Kevin W.-H. Lo. Bone Regenerative Engineering Using a Protein Kinase A-Specific Cyclic AMP Analogue Administered for Short Term. Regenerative Engineering and Translational Medicine. (August 2018)

M. M. Cloutier J, F. Wiley, C. ‐L. Kuo, T. Cornelius, Z. Wang, A. A. Gorin. Outcomes of an early childhood obesity prevention program in a low‐income community: a pilot, randomized trial. Pediatric Obesity. (August 2018)

Mo A, Wu R, Grady JP, Hanley MP, ToroM, Swede H, Devers TJ, Hartman TJ, Rosenberg DW8. Associations of dietary fat with risk of early neoplasia in the proximal colon in a population-based case-control study. Cancer Causes & Control (July 2018)

Alise Frallicciardi, Seth Lotterman, Matthew Ledford, Ilana Prenovitz, Rochelle Van Meter, Chia-Ling Kuo, Thomas Nowicki, Robert Fuller, Sam Clarke. Training for Failure: A Simulation Program for Emergency Medicine Residents to Improve Communication Skills in Service Recovery. AEM Education & Training. (July 2018)

Schwartz MA, Naples JG, Kuo CL, Falcone TE. Opioid Prescribing Patterns among Otolaryngologists. Otolaryngol Head Neck Surg. (May 2018)

Moy BT, Forouhar F, Kuo CL, Devers TJ. Endoscopic Features of Mucous Cap Polyps: A Way to Predict Serrated Polyps. Clin Endosc. (April 2018)

Kuo CL, Duan Y, Grady J. Unconditional or Conditional Logistic Regression Model for Age-Matched Case-Control Data?, Front Public Health. (March 2018)

Zhou W, Liu Z, Song L, Kuo CL, Shafer DM. Clinical factors affecting the accuracy of guided implant surgery-a systematic review and meta-analysis. J Evid Based Dent Pract. (March 2018)

Noel JK, Babor TF, Grady JJ. Advertising Content, Platform Characteristics and the Appeal of Beer Advertising on a Social Networking Site. Alcohol Alcohol. (March 2018)

Duan Y, Grady JJ, Albertsen PC, Helen Wu Z. Tamsulosin and the risk of dementia in older men with benign prostatic hyperplasia. Pharmacoepidemiol Drug Saf. (March 2018)

Zhou W, Liu Z, Song L, Kuo CL, Shafer DM. Clinical Factors Affecting the Accuracy of Guided Implant Surgery-A Systematic Review and Meta-analysis. J Evid Based Dent Pract. (March 2018)

Drew DA, Mo A, Grady JJ, Stevens RG, Levine JB, Brenner BM, Anderson JC, Forouhar F, O'Brien MJ, Devers TJ, Rosenberg DW. Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and Are Primed for Neoplastic Progression. Mol Cancer Res. (March 2018)

Nakanishi M, Hanley MP, Zha R, Igarashi Y, Hull MA, Mathias G, Sciavolino F, Grady JJ, Rosenberg DW. A novel bioactive derivative of eicosapentaenoic acid (EPA) suppresses intestinal tumor development in ApcΔ14/+ mice. Carcinogenesis. (March 2018)

Torre K, Jhorar P, Wu R, Pfeifer J, Elaba Z, Murphy M. Molecular testing practices and perceptions among dermatopathologists. Journal of Cutaneous Pathology. (February 2018)

Chhibber A, Agarwal S, Yadav S, Kuo CL, Upadhyay M. Which orthodontic appliance is best for oral hygiene? A randomized clinical trial. Am J Orthod Dentofacial Orthop. (February 2018)

Curry EJ, Ke K, Chorsi MT, Wrobel KS, Miller AN 3rd, Patel A, Kim I, Feng J, Yue L, Wu Q, Kuo CL, Lo KW, Laurencin CT, Ilies H, Purohit PK, Nguyen TD. Biodegradable Piezoelectric Force Sensor. Proc Natl Acad Sci USA. (January 2018)

Bidra AS, Nguyen V, Manzotti A, Kuo CL. Differences in Lip Support with and without Labial Flanges in a Maxillary Edentulous Population Part 3: Unblinded and Discriminatory Subjective Analysis. J Prosthodont. (January 2018)

Curry EJ, Ke K, Chorsi MT, Wrobel KS, Miller III AN, Patel A, Kim I, Feng J, Yue L, Wu Q, Kuo CL, Lo KW, Laurencin C, Ilies H, Purohit PK, Nguyen TD. Biodegradable piezoelectric force sensor. National Acad Sciences. (January 2018)


Drew DA, Mo A, Grady JJ, Stevens RG, Levine JB, Brenner BM, Anderson JC, Forouhar F, O'Brien MJ, Devers TJ, Rosenberg DW. Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and are Primed for Neoplastic Progression. Mol Cancer Res. (December 2017)

Pilling LC, Kuo CL, Sicinski K, Tamosauskaite J, Kuchel GA, Harries LW, Herd P, Wallace R, Ferrucci L, Melzer D. Human longevity: 25 genetic loci associated in 389,166 UK biobank participants. Aging. (December 2017)

Steffens DC, Wu R, Grady JJ, Manning KJ. Presence of neuroticism and antidepressant remission rates in late-life depression: results from the Neurobiology of Late-Life Depression (NBOLD) study. Int Psychogeriatr. (December 2017)

Nakanishi M, Hanley MP, Zha R, Igarashi Y, Hull MA, Mathias G, Sciavolino F, Grady JJ,  Rosenberg DW. A novel bioactive derivative of eicosapentaenoic acid (EPA) suppresses intestinal tumor development in ApcΔ14/+ mice. Carcinogenesis. (December 2017)

Lyapis A, Ulrich A, LaMonica R, Kuo CL, Kaye L, Luciano D. Does the difference in fascial closure technique affect post-operative pain? J Minim Invasive Gynecol. Elsevier Inc. (November 2017)

Townsel C, Keller R, Kuo CL, Campbell WA, Hussain N. Racial/ethnic disparities in morbidity and mortality for preterm neonates admitted to a tertiary neonatal intensive care unit. J Racial Ethn Health Disparities. (October 2017)

Mather JF, Corradi JP, Waszynski C, Noyes A, Duan Y, Grady J, Dicks R. Statin and Its Association With Delirium in the Medical ICU. Crit Care Med. (September 2017)

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo CL, Ruth KS, Tuke MA, Yaghootkar H, Freathy RM, Wood AR, Murray A, Weedon MN, Harries LW, Kuchel GA, Ferrucci L, Frayling TM, Melzer D. Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers. PLoS One. (September 2017)

DambskaM, Labrador EB, Kuo CL, Weinstein DA. Prevention of complications in glycogenstorage disease type Ia with optimization of metabolic control. Pediatr Diabetes. (August 2017)

Wu Z, Barry L, Duan Y, Bohannon R, Covault JM, Grady JJAcute Effects of Moderate Alcohol Consumption on Postural Stability in Older Adults. Percept Mot Skills. (July 2017)

Salber GJ, Wang YB, Lynch JT, Pasquale KM, Rajan TV, Stevens RG, Grady JJ, Kenny AM. Metformin Use in Practice: Compliance With Guidelines for Patients With Diabetes and Preserved Renal Function. Clin Diabetes. (July 2017)

Andrews R, Chamberlin KW, Ingrassia J, Kuo CL, Pizzi A, Wolf JM. 5 step guide to conversations between trainees and patients in pain: educating trainees about discontinuing opioids using a staged approach. J Family Med Community Health. (July 2017)

Babapoor S, Wu R, Kozubek J, Auidi D, Grant-Kels JM, Dadras SS. Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. Lab Invest. (June 2017)

Bidra AS, Zapata G, Agar JR, Taylor TD, Grady J.  Differences in Lip Support with and without Labial Flanges in a Maxillary Edentulous Population. Part 1: Objective Analysis. J Prosthodont. (May 2017)

Moy BT, Forouhar F, Kuo CL, Devers TJ. Endoscopic features of mucous cap polyps during colonoscopy: A retrospective study predicting serrated polyps. Clin Endosc. (May 2017)

Oncken C, Ricci KA, Kuo CL, Dornelas E, Kranzler HR, Sankey HZ.  Correlates of electronic cigarettes use before and during pregnancy. Nicotine Tob Res. (May 2017)

Roy B, McCullough LD, Dhar R, Grady J, Wang YB, Brown RJ. Comparison of Initial Vasopressors Used for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage. Cerebrovasc Dis. (March 2017)

Hoag JR, Kuo CL. Chapter 3: Normal and non-normal data simulations for the evaluation of twosample location tests. Monte Carlo Simulation-Based Statistical Modeling. Springer Singapore, 41-57. (February 2017)

Datta D, Foley RJ, Wu R, Grady J, Scalise P. Renal Function, Weaning, and Survival in Patients With Ventilator-Dependent Respiratory Failure. J Intensive Care Med. (January 2017)


Fortinsky RH, Gitlin LN, Pizzi LT, Piersol CV, Grady J, Robison JT, Molony S. Translation of the Care of Persons with Dementia in their Environments (COPE) intervention in a publicly-funded home care context: Rationale and research design. Contemp Clin Trials. (Jul 2016)

Naples JG, Spiro J, Tessema B, Kuwada C, Kuo CL, Brown SM. Neck recurrence and mortality in esthesioneuroblastoma: Implications for management of the N0 neck. Laryngoscope. (June 2016)

Carpinnello OJ, Casson PR, Kuo CL, Raj RS, Sills ES, Jones CA. Costimplications for subsequent perinatal outcomes after IVF stratified by number of embryos transferred: A five year analysis of Vermont data. Appl Health Econ Health Policy. (June 2016)

Datta D, Foley R, Wu R, Grady J, Scalise P. Can Creatinine Height Index Predict Weaning and Survival Outcomes in Patients on Prolonged Mechanical Ventilation After Critical Illness? J Intensive Care Med. (May 2016)

Bidra AS, Farrell K, Burnham D, Dhingra A, Taylor TD, Kuo CLProspective cohort pilot study of 2-visit CAD/CAM monolithic complete dentures and implant-retained overdentures: Clinical and patientcentered outcomes. J Prosthet Dent. (May 2016)

Gohil SV, Kuo CL, Adams DJ, Maye P, Rowe DW, Nair LS. Evaluation of the donor cell contribution in rhBMP2 mediated bone formation with chitosan thermogels using fluorescent protein reporter mice. J Biomed Mater Res A. (April 2016)

Santos J, Jones S, Wakefield D, Grady J, Andemariam B. Patient Controlled Analgesia for Adults with Sickle Cell Disease Awaiting Admission from the Emergency Department. Pain Res Manag. (March 2016)

Silver E, Wu R, Grady J, Song L. Knot Security- How is it Affected by Suture Technique, Material, Size, and Number of Throws? J Oral Maxillofac Surg. (July 2016)

Works T, Jones S, Grady JJ, Andemariam B. Traumatic Exposure History as a Risk Factor for Chronic Pain in Adult Patients with Sickle Cell Disease. Health Soc Work. (February 2016)

Babapoor S, Horwich M, Wu R, Levinson S, Gandhi M, Makkar H, Kristjansson A, Chang M, Dadras SS. microRNA in situ hybridization for miR-211 detection as an ancillary test in melanoma diagnosis. Mod Pathol. (February 2016)

Drew DA, Goh G, Mo A, Grady JJ, Forouhar F, Egan G, Swede H, Rosenberg DW, Stevens RG, Devers TJ. Colorectal polyp prevention by daily aspirin use is abrogated among active smokers. Cancer Causes Control. (January 2016)

Salman M, Pike D, Wu R, Oncken C. Effectiveness and Safety of a Clinical Decision Rule to Reduce Repeat Ionized Calcium Testing: a PRE/POST Test Intervention.Connecticut Medicine. (Jan 2016)

Hoag JR, Kuo CL. Ranking question designs and analysis methods. J Med Stat Inform, (2016)


Steffens DC, Manning KJ, Wu R, Grady JJ, Fortinsky RH, Tennen HA. Methodology and preliminary results from the neurobiology of late-life depression study. Int Psychogeriatr. (December 2015)

Works, T., Jones. S., Grady, JJ, Andemariam, B. Traumatic Exposure History as a Risk Factor for Chronic Pain in Adult Patients with Sickle Cell Disease. Health & Social Work. (December 2015)

Wu, Z.H., Stevens R., Tennen H., North C.S., Grady J.J.,  Holzer, C.. Sleep quality among low income young women predicts changes in perceived stress before and after Hurricane Ike in Southeast Texas. Sleep (July 2015)


Babapoor S, Fleming E, Wu R, Dadras SS. A novel miR-451a isomiR, associated with amelanotypic phenotype, acts a tumor suppressor in melanoma by retarding cell migration and invation. PLoS One. (September 2014)

Yang, T., Shen, J.-B., Yang, R., Redden, J., Dodge-Kafka, K., Grady, J.J., Jacobson, K.A.b, Liang, B.T. Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure. Circulation: Heart Failure. (May 2014)

Gurram, P., Benn, P., Grady, J.J., Prabulos, A.M., and Campbell, W. First Trimester Aneuploidy Screening Markers in Women with Pre-Gestational Diabetes Mellitus. J. Clin. Med. (May 2014)

Andemariam B, Owarish-Gross J, Grady JJ, Boruchov D, Thrall RS, Hagstrom JN. Identification of risk factors for an unsuccessful transition from pediatric to adult sickle cell disease care. Pediatr Blood Cancer. (April 2014)

Albertsen, P.C., Klotz, L., Tombal, B., Grady, J.J., Olesen, T.K., Nilsson, J. Cardiovascular morbidity associated with gonadotropin releasing hormone agonists and an antagonist. European Urology. (March 2014)


Farrokhi V, Nemati R, Nichols FC, Yao X, Anstadt E, Fujiwara M, Grady JJ, Wakefield D, Castro W, Donaldson J, and Clark RB.  Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis. Clinical & Translational Immunology. (November 2013)

Martin KS, Wu R, Wolff M, Colantonio AG, Grady J. A novel food pantry program: food security, self-sufficiency, and diet-quality outcomes. Am J Prev Med. (November 2013)

Kozubek J, Ma Z, Fleming E, Duggan T, Wu R, Shin DG, Dadras SS. In-depth characterization of microRNA transcriptome in melanoma. PLoS One. (September 2013)

Drew DA, Devers T, Horelik N, Yang S, O'Brien M, Wu R, Rosenberg DW. Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions. Proteomics. (May 2013)


Duan F, Simeone S, Wu R, Grady J, Mandoiu I, Srivastava PK. Area under the curve as a tool to measure kinetics of tumor growth in experimental animals. J Immunol Methods. (August 2012)