Synthesis, Physicochemical Analysis, and Side Group Optimization of Degradable Dipeptide-Based Polyphosphazenes as Potential Regenerative Biomaterials depicts the synthetic and design flexibility of polyphosphazene polymers that provides a versatile platform for the fine-tuning and modulation of material properties. This property control ultimately leads to a class of biomaterials with a wide range of physicochemical and biological properties that can meet specific requirements for different tissue regenerative engineering and other biomedical applications. The composition‒structure‒properties relationships of the polyphosphazene biomaterials are fully presented. The image shows the scheme of the macromolecular substitution, the second image shows the flexible platform provided by the macromolecular substitution and hydrogen bonding capability of the dipeptide side groups, and the third shows the resultant materials with a wide range of properties that can be adopted in many different regenerative purposes. The two-headed arrow indicates a wide range and diversity.
CT Convergence Institute contributors- Dr. Cato T. Laurencin, Kenneth S. Ogueri, Riley H. Blumenfield, Jorge L. Escobar Ivirico