{"id":332,"date":"2017-10-24T11:25:09","date_gmt":"2017-10-24T15:25:09","guid":{"rendered":"https:\/\/health.uconn.edu\/cell-biology\/?page_id=332"},"modified":"2025-06-23T07:22:42","modified_gmt":"2025-06-23T11:22:42","slug":"mark-terasaki","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/cell-biology\/faculty-and-staff\/mark-terasaki\/","title":{"rendered":"Mark Terasaki"},"content":{"rendered":"

\"MarkAssociate Professor
\nDepartment of Cell Biology<\/p>\n

Contact<\/h3>\n

Phone: 860-679-2695
\nEmail: terasaki@uchc.edu<\/a>
\nmarkterasaki@me.com<\/a>
\nOffice: E6037<\/p>\n

UConn Health
\n263 Farmington Avenue
\nFarmington, CT 06030<\/p>\n

Research Interests<\/h3>\n

Structure and function of the endoplasmic reticulum; serial section electron microscopy; plasma membrane re-sealing; mechanism of nuclear envelope breakdown.<\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Lab Members<\/a><\/p>\n

 <\/p>\n

Selected Publications<\/h3>\n

Miki Furusho and Mark Terasaki. Evidence for glia-mediated, age-dependent remodeling of myelin at the axon initial segment<\/a>. J Comp Neurol<\/em>. 2024. Feb;532(2):e25574.\u00a0<\/span>\u00a0<\/span>doi: 10.1002\/cne.25574.<\/span><\/p>\n

Wood BM, Baena V, <\/span>Huang H, Terasaki M, Kornberg TB. Cytonemes with complex geometries and composition extend to invaginations of target cells.<\/a> J Cell Biol.<\/em> 2021. 220(5):e202101116.<\/span>\u00a0<\/span>doi: 10.1083\/jcb.202101116<\/span><\/p>\n

Antel M, <\/span><\/span>Baena V, <\/span><\/span>Terasaki M , <\/span><\/span>Inaba M. \u00a0<\/span><\/sup><\/span>Ultrastructural Analysis of Cell-Cell Interactions in Drosophila Ovary<\/a>. Methods Mol Biol<\/em>. 2021. 2346:79-90. <\/span>\u00a0doi: 10.1007\/7651_2020_342.<\/span><\/p>\n

Norris RP,\u00a0Terasaki M. <\/em>Gap junction internalization and processing in vivo: a 3D immuno-electron microscopy study.<\/a> J Cell Sci. <\/em><\/span><\/span>2021. 134(1):jcs252726.<\/span>\u00a0doi: 10.1242\/jcs.252726<\/span><\/div>\n

Terasaki M, <\/span><\/span>Brunson JC,\u00a0<\/span>Sardi J.\u00a0<\/span>Analysis of the three dimensional structure of the kidney glomerulus capillary network<\/a>. Sci Rep.\u00a0<\/em>2020. 10(1):20334. <\/span>doi: 10.1038\/s41598-020-77211-x.<\/span><\/p>\n

\n

Shuhaibar N, <\/span><\/span>Hand AR,\u00a0<\/span>Terasaki M.<\/span>\u00a0Odontoblast processes of the mouse incisor are plates oriented in the direction of growth<\/a>. Anat Rec (Hoboken)<\/em>.\u00a0<\/span><\/span>2021. 304 (8): 1820-1827. <\/span>doi: 10.1002\/ar.24570.<\/span><\/p>\n<\/div>\n

Baena, V., Owen, C.M., Uliasz, T.F., Lowther, K.M., Yee, S.-P., Terasaki, M., Egbert, J., Jaffe, L.A., Cellular heterogeneity of the LH receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles<\/a>. Endocrinology<\/em> 2020. <\/span>161(7):bqaa074.<\/span> doi: 10.1210\/endocr\/bqaa074.<\/span><\/p>\n

Ramesh Iyer,\u00a0<\/span><\/span>Oliver Monfredi,\u00a0<\/span><\/span>Manuela Lavorato,\u00a0<\/span><\/span>Mark Terasaki <\/span><\/sup>,\u00a0<\/span><\/span>Clara Franzini-Armstrong, <\/span>2020. <\/span>Ultrastructure of primary pacemaking cells in rabbit sino-atrial node cells indicates limited sarcoplasmic reticulum content.<\/a>\u00a0 FACEB<\/em>\u00a0Bioadv. <\/em>2020. 2(2):106-115.<\/span>\u00a0doi: 10.1096\/fba.2018-00079.<\/span><\/p>\n

Kate A Rawlinson,\u00a0<\/span><\/span>Francois Lapraz,\u00a0<\/span><\/span>Edward R Ballister,\u00a0<\/span><\/span>Mark Terasaki,\u00a0<\/span><\/span>Jessica Rodgers,\u00a0<\/span><\/span>Richard J McDowell,\u00a0<\/span><\/span>Johannes Girstmair,\u00a0<\/span><\/span>Katharine E Criswell,\u00a0<\/span><\/span>Miklos Boldogkoi,\u00a0<\/span><\/span>Fraser Simpson,\u00a0<\/span><\/span>David Goulding,\u00a0<\/span><\/span>Claire Cormie,\u00a0<\/span><\/span>Brian Hall,\u00a0<\/span><\/span>Robert J Lucas,\u00a0<\/span><\/span>Maximilian J Telford, <\/span>Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment.<\/a> eLife<\/em> 2019. 8:e45465. <\/span>doi: 10.7554\/eLife.45465.<\/span><\/p>\n

Baena V, Schalek RL, Lichtman JW, Terasaki M. Serial-section electron microscopy using automated tape-collecting ultramicrotome (ATUM).<\/a> \u00a0Methods Cell Biol. 2019;152:41-67.<\/p>\n

Valentina Baena\u00a0&\u00a0Mark Terasaki. Three-dimensional organization of transzonal projections and other cytoplasmic extensions in the mouse ovarian follicle<\/a>.\u00a0Scientific Reports\u00a0<\/i>9 (2019<\/span>), Article\u00a0number:\u00a01262.<\/span><\/p>\n

Bryan A. Niedenberger,\u00a0Kenneth Cook, Valentina Baena, Nicholas D. Serra, Ellen K. Velte, Julio E. Agno, Karen A. Litwa, Mark Terasaki, Brian P. Hermann, Martin M. Matzuk, and Christopher B. Geyer.\u00a0Dynamic cytoplasmic projections connect mammalianspermatogonia in vivo.<\/a>\u00a0Development<\/em>\u00a0<\/span>2018. <\/span>145:\u00a0<\/span>dev161323\u00a0<\/span>doi:\u00a010.1242\/dev.161323<\/span><\/p>\n

Terasaki M.\u00a0Axonal endoplasmic recticulum is very narrow.<\/a>\u00a0J Cell Sci. 2018. 131(4): jcs210450.<\/p>\n

Darras S, Fritzenwanker JH, Uhlinger KR, Farrelly E, Pani AM, Hurley IA, Norris RP, Osovitz M, Terasaki M, Wu M, Aronowicz J, Kirschner M, Gerhart JC, Lowe CJ. Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development<\/a> PLoS Biol<\/em>. 2018. 16(1):e2003698.<\/p>\n

Yal\u00e7\u0131n B, Zhao L, Stofanko M, O’Sullivan NC, Kang ZH, Roost A, Thomas MR, Zaessinger S, Blard O, Patto AL, Sohail A, Baena V, Terasaki M<\/strong>, O’Kane CJ. Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins<\/a>\u00a0Elife. 2017. 6: e23882.<\/p>\n

Norris RP, Baena V, Terasaki M. Localization of phosphorylated connexin 43 by serial section immunogold electron microscopy.<\/a>\u00a0J Cell Sci.<\/em> 2017. 130: 1333-1340.<\/p>\n

Terasaki, M. A finer look at a fine cellular meshwork.<\/a> Science<\/em>. 2016 Oct 28;354(6311):415-416.<\/p>\n

Terasaki, M., Shemesh, T., Kasthuri, N., Klemm, R.W., Schalek, R., Hayworth, K.J., Hand, A.R., Yankova, M., Huber, G., Lichtman, J.W., Rapoport, T., and Kozlov, M.M. 2013. Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs.<\/em><\/a> Cell<\/em> 154: 285-296.\u00a0See also Cell Preview: Marshall, W.F. 2013. Differential geometry meets the cell.<\/a> Cell<\/em> 154: 265-266.<\/p>\n

 <\/p>\n

\"Geometry<\/p>\n

 <\/p>\n

This paper explains how parallel sheets of endoplasmic reticulum are connected. The existence of these sheet stacks and their function in synthesis of membrane and secreted proteins has been known for more than 60 years. Three-dimensional reconstructions from serial section electron micrographs from the mouse salivary gland show that the sheets are connected by twisted membrane surfaces with helical edges. The overall structure resembles a parking garage, in which the different levels are connected by helicoidal ramps. Theoretical calculations show that this structure minimizes the elastic energy of sheet edges and surfaces and allows dense packing of this organelle in the restricted space of a cell.<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

Green, S.A., Norris, R.P., Terasaki, M., Lowe, C.J. 2013. FGF signaling induces mesoderm in the hemichordate Saccoglossus kowalevskii.<\/a> Development<\/em> 140: 1024-1033.<\/p>\n

Darra, S., Gerhart, J., Terasaki, M., Kirschner, M., Lowe, C.J. 2011. b-Catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate\u00a0Saccoglossus kowalevskii<\/a>. Development<\/em> 138, 959-970.<\/p>\n

Terasaki, M., and Runft, L. 2010. Two-stage dependence for 1-methyladenine induced reinitiation of meiotic maturation in starfish oocytes.<\/a> Exp. Cell Res.<\/em> 316: 2654-2663.<\/p>\n

Lowe, C.J., Terasaki, M., Wu, M., Freeman, R., Runft, L., Kwan, K., Haigo, S., Aronowicz, J., Lander, E., Gruber, C., Kirschner, M., and Gerhart, J. 2006. Dorsoventral patterning in hemichordates: insights into early chordate evolution<\/a>. PLOS<\/em> 4: 1603-1619.<\/p>\n

Terasaki, M. 2006. Fluorescence quantitation in thick specimens, with an application to cyclin B-GFP expression in starfish oocytes<\/a>. Biol. Cell<\/em> 98: 245-252.<\/p>\n

Fein, A., and Terasaki, M. 2005. Rapid increase in plasma membrane chloride permeability during wound resealing in starfish oocytes.<\/a> J. Gen. Physiol.<\/em> 126: 151-159.<\/p>\n

Lenart, P., Daigle, N., Bacher, C., Hand, A.R. , Eils, R., Terasaki, M., and Ellenberg, J. 2005. A contractile nuclear actin network drives chromosome congression in oocytes<\/a>. Nature<\/em> 436: 812-818.<\/p>\n

Terasaki, M., Okumura, E., Hinkle, B., and Kishimoto, T. 2003. Localization and dynamics of Cdc2-cyclin B during meiotic reinitation in starfish oocytes.<\/a> Mol. Biol. Cell <\/em>14:4685-4694.<\/p>\n

Slepchenko, B.M., and Terasaki, M. 2003. Cyclin aggregation and robustness of bio-switching<\/a>. Mol. Biol. Cell<\/em> 14: 4695-4706.<\/p>\n

Galbraith, J.A., and Terasaki, M. 2003. Controlled damage in thick specimens by multiphoton excitation.<\/a> Mol. Biol. Cell <\/em>14: 1808-1817.<\/p>\n

Hinkle, B., Slepchenko, B., Rolls, M.M., Walther, T.C., Stein, P.A., Mehlmann, L.M., Ellenberg, J., and Terasaki, M. 2002. Chromosomal association of Ran during meiotic and mitotic divisions.<\/a> J. Cell Sci.<\/em> 115: 4685-4693.<\/p>\n

Terasaki, M., Runft, L., and Hand, A. 2001. Changes in organization of the endoplasmic reticulum during Xenopus oocyte maturation and egg activation<\/a>. Mol. Biol. Cell<\/em> 12: 1103-1116.<\/p>\n

Terasaki, M., Campagnola, P., Rolls, M.M., Stein, P., Ellenberg, J., Hinkle, B., and Slepchenko, B. 2001. A new model for nuclear envelope breakdown.<\/a> Mol. Biol. Cell<\/em> 12: 503-510.<\/p>\n","protected":false},"excerpt":{"rendered":"

Associate Professor Department of Cell Biology Contact Phone: 860-679-2695 Email: terasaki@uchc.edu markterasaki@me.com Office: E6037 UConn Health 263 Farmington Avenue Farmington, CT 06030 Research Interests Structure and function of the endoplasmic reticulum; serial section electron microscopy; plasma membrane re-sealing; mechanism of nuclear envelope breakdown.   Lab Members   Selected Publications Miki Furusho and Mark Terasaki. Evidence […]<\/p>\n","protected":false},"author":187,"featured_media":0,"parent":69,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-27 02:03:40","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/332"}],"collection":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/users\/187"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/comments?post=332"}],"version-history":[{"count":29,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/332\/revisions"}],"predecessor-version":[{"id":3856,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/332\/revisions\/3856"}],"up":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/69"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/media?parent=332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}