{"id":1889,"date":"2020-04-23T10:59:22","date_gmt":"2020-04-23T14:59:22","guid":{"rendered":"https:\/\/health.uconn.edu\/cell-biology\/?page_id=1889"},"modified":"2022-10-20T07:40:37","modified_gmt":"2022-10-20T11:40:37","slug":"dodge-kafka-lab","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/cell-biology\/dodge-kafka-lab\/","title":{"rendered":"Dodge-Kafka Lab"},"content":{"rendered":"<div id=\"pl-1889\"  class=\"panel-layout\" ><div id=\"pg-1889-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-1889-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1889-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><h3 class=\"widget-title\">Current Members<\/h3><div class=\"textwidget\"><\/div><\/div><\/div><\/div><div id=\"pg-1889-1\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-1889-1\" ><div id=\"pgc-1889-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1889-1-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><h4>Moira Renee Agcaoili<a href=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/agcaoili-picture.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/agcaoili-picture-235x300.jpg\" alt=\"Moira Agcaoili\" width=\"110\" height=\"141\" class=\"alignright wp-image-2613\" srcset=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/agcaoili-picture-235x300.jpg 235w, https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/agcaoili-picture.jpg 657w\" sizes=\"(max-width: 110px) 100vw, 110px\" \/><\/a><\/h4>\n<p>Undergraduate Student<br \/>\nPhone: 860-679-4204<br \/>\nEmail: <a href=\"mailto:moira_renee.agcaoili@uconn.edu\">moira_renee.agcaoili@uconn.edu<\/a><\/p>\n<p>I am an undergraduate student researcher currently pursuing a B.S. in Physiology and Neurobiology with a French minor. I joined the Dodge-Kafka lab in my senior year of high school and worked on an independent project through which I received my first hands-on experience in a research lab setting. During my time at UConn, I also worked as a lab technician and developed my technical skills in different staining protocols and fluorescent microscopy. As part of my ongoing UConn Honors thesis, I currently use various beta blockers and mAKAP-specific reagents to understand the mechanism in which nuclear beta-adrenergic receptors mediate cardiomyocyte apoptosis via the mAKAP scaffold protein.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-1889-2\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-1889-2\" ><div id=\"pgc-1889-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1889-2-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"2\" ><div class=\"textwidget\"><h4>Bryan Cernuda<\/h4>\n<p><span>Ph.D. Biomedical Science Student<\/span><br \/>\nPhone: 860-679-4204<br \/>\nEmail: <a href=\"mailto:cernuda@uchc.edu\" rel=\"\">cernuda@uchc.edu<\/a><\/p>\n<p>&nbsp;<\/p>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-1889-3\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-1889-3-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1889-3-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"3\" ><div class=\"textwidget\"><h4><a href=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/Sofia-Possidento-Picture_.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/Sofia-Possidento-Picture_-206x300.jpg\" alt=\"Sofia Possidento \" width=\"111\" height=\"162\" class=\"alignright wp-image-2607\" srcset=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/Sofia-Possidento-Picture_-206x300.jpg 206w, https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/Sofia-Possidento-Picture_.jpg 575w\" sizes=\"(max-width: 111px) 100vw, 111px\" \/><\/a>Sofia Marie Possidento<\/h4>\n<p><span>Ph.D. Biomedical Science Student<\/span><br \/>\nPhone: 860-679-4204<br \/>\nEmail: <a href=\"mailto:possidento@uchc.edu\">possidento@uchc.edu<\/a><\/p>\n<p><span style=\"font-size: 10.0pt; font-family: 'Arial',sans-serif; color: black; background: white;\">I am a second year biomedical science PhD student in the Dodge-Kafka lab. I graduated with a B.S. in biomedical science from Quinnipiac University, where I minored in microbiology and immunology. I also have a M.S. in biomedical science from Quinnipiac, where I did my Master\u2019s thesis on the role of MYC and YDJC in breast cancer progression. Here in the Dodge-Kafka Lab, I study perinuclear ryanodine receptor mediated calcium release around the scaffold protein mAKAP. In our lab, I use novel peptides localized to mAKAP with various microscopy techniques to investigate the source of calcium that drives calcium mediated gene transcription to uncover the molecular mechanism behind cardiac hypertrophy.\u00a0<\/span><span style=\"font-family: 'Calibri',sans-serif; color: black;\"><o:p><\/o:p><\/span><\/p>\n<p>&nbsp;<\/p>\n<\/div><\/div><\/div><\/div><div id=\"pg-1889-4\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-1889-4-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1889-4-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"4\" ><div class=\"textwidget\"><h4><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2020\/04\/gildart-moriah-20190403-0867-crop-788x1024.jpg\" alt=\"Turcotte photo\" width=\"120\" height=\"156\" class=\"alignright\" \/>Moriah Turcotte<\/h4>\n<p>Post Doctoral Fellow<br \/>\nPhone: 860-679-1362<br \/>\nEmail: <a href=\"mailto:mturcotte@uchc.edu\">mturcotte@uchc.edu<\/a><\/p>\n<p><span style=\"font-family: 'Calibri',sans-serif; color: black;\">As a University Post Doctoral Fellow in the Dodge-Kafka Lab, my main project concerns the role of perinuclear beta-adrenergic receptors in cardiac hypertrophy. I received my Ph.D. in 2021 at UConn Health where I began this project, and also published on mAKAP regulated perinuclear calcium transients required for cardiac hypertrophy. I received my BS in Biology with Honors from the University of Saint Joseph in West Hartford, CT. I joined the Dodge-Kafka Lab in 2013 for my senior undergrad capstone project, which concerned mAKAP-dependent PKA activity and led to a lab technician position. My practical expertise lies in live-cell imaging and FRET technology, as well as cardiomyocyte isolation and culture.<a href=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/mAKAP-regulated-perinuclear-calcium-transients-Tucotte-model.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/mAKAP-regulated-perinuclear-calcium-transients-Tucotte-model.jpg\" alt=\"\" width=\"472\" height=\"296\" class=\"aligncenter size-full wp-image-2628\" srcset=\"https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/mAKAP-regulated-perinuclear-calcium-transients-Tucotte-model.jpg 472w, https:\/\/health.uconn.edu\/cell-biology\/wp-content\/uploads\/sites\/115\/2022\/08\/mAKAP-regulated-perinuclear-calcium-transients-Tucotte-model-300x188.jpg 300w\" sizes=\"(max-width: 472px) 100vw, 472px\" \/><\/a><o:p><\/o:p><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: 'Calibri',sans-serif; color: black;\"><o:p>\u00a0<\/o:p><\/span><\/p>\n<\/div><\/div><\/div><\/div><div id=\"pg-1889-5\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-1889-5-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1889-5-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"5\" ><div class=\"textwidget\"><h3>Former Members<\/h3>\n<ul>\n<li>Kristen Tokarski: MD\/PhD student, UConn medical school<\/li>\n<li>Shania Aponte Paris: Master's mentor (2016-2019), as part of the YIIP program at UConn Health.\u00a0 Currently in Medical School in Puerto Rico at San Juan Bautista.<\/li>\n<li>Akilah Plair: Master's mentor (2014-2016), Akilah is part of the YIIP program at UConn Health.\u00a0 4<sup>th<\/sup> Year Naturopathic Medical Student at University of Bridgeport.<\/li>\n<li>Marc Rigatti - PhD mentor (2012-2015).\u00a0 Graduated from UConn Health MD\/PhD program.\u00a0 Emergency Physician at UConn Health.<\/li>\n<li>Arpita Singh - PhD mentor (2008-2013).\u00a0 Clinical Trial Manger at Oticon Medical AB.<\/li>\n<li>Andrew Le - PhD mentor (2008-2013).\u00a0 Currently in Physician Scientist School at Yale University.<\/li>\n<li>John Redden - PhD mentor (2008-2013).\u00a0 Associate Professor-in-Residence at UConn, Department of Physiology and Neurobiology.<\/li>\n<li>Maximilian Vargas - PhD mentor (2007-2012). Senior Director for US Access Strategy.<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Moira Renee Agcaoili Undergraduate Student Phone: 860-679-4204 Email: moira_renee.agcaoili@uconn.edu I am an undergraduate student researcher currently pursuing a B.S. in Physiology and Neurobiology with a French minor. I joined the Dodge-Kafka lab in my senior year of high school and worked on an independent project through which I received my first hands-on experience in a [&hellip;]<\/p>\n","protected":false},"author":305,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-19 09:02:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/1889"}],"collection":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/users\/305"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/comments?post=1889"}],"version-history":[{"count":57,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/1889\/revisions"}],"predecessor-version":[{"id":2676,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/1889\/revisions\/2676"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/media?parent=1889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}