{"id":1582,"date":"2019-12-09T09:12:09","date_gmt":"2019-12-09T14:12:09","guid":{"rendered":"https:\/\/health.uconn.edu\/cell-biology\/?page_id=1582"},"modified":"2019-12-09T15:52:04","modified_gmt":"2019-12-09T20:52:04","slug":"curriculum-vitae-laurinda-a-jaffe","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/cell-biology\/curriculum-vitae-laurinda-a-jaffe\/","title":{"rendered":"Curriculum Vitae, Laurinda A. Jaffe"},"content":{"rendered":"

 <\/p>\n\n\n\n\n\n\n\n\n
ADDRESS:<\/u><\/td>\nDepartment of Cell Biology<\/td>\n<\/tr>\n
<\/td>\nUniversity of Connecticut Health Center<\/td>\n<\/tr>\n
<\/td>\nFarmington, CT 06030 USA<\/td>\n<\/tr>\n
<\/td>\nPhone:\u00a0 (860)\u00a0 679-2661<\/td>\n<\/tr>\n
<\/td>\ne-mail:\u00a0\u00a0 ljaffe@uchc.edu<\/td>\n<\/tr>\n
BIRTH<\/u>:<\/td>\nJanuary 9, 1952, Pasadena, CA<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

EDUCATION:<\/u><\/p>\n\n\n\n\n\n\n\n
University of Wisconsin, Madison, WI<\/td>\n1969-1971<\/td>\n<\/tr>\n
Purdue University, W. Lafayette, IN<\/p>\n

B.S. (biology)<\/td>\n

1971-1973<\/td>\n<\/tr>\n
University of California, Los Angeles, CA<\/p>\n

Ph.D. (biology; advisor: Susumu Hagiwara)<\/td>\n

1974-1977<\/td>\n<\/tr>\n
Marine Biological Laboratory, Woods Hole, MA<\/p>\n

post-doc (advisor: Lewis Tilney)<\/td>\n

1978-1979<\/td>\n<\/tr>\n
University of California, San Diego, CA<\/p>\n

post-doc (advisor: Meredith Gould)<\/td>\n

1979-1981<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

FACULTY POSITIONS<\/u>:<\/p>\n

University of Connecticut Health Center, Farmington, CT<\/p>\n\n\n\n\n\n
Assistant Professor – Professor<\/td>\n1981-present<\/td>\n<\/tr>\n
Interim Chair<\/td>\n2006-2011<\/td>\n<\/tr>\n
Chair<\/td>\n2011-present<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

AWARDS:<\/u><\/p>\n

UConn Health Loeser Award for Outstanding Teaching, 1988<\/p>\n

National Science Foundation Faculty Award for Women, 1991-1997<\/p>\n

Human Frontier Science Program Award, 2000-2004<\/p>\n

Fellow, American Association for the Advancement of Science, 2007<\/p>\n

MERIT Award, NICHD, 2014-2024<\/p>\n

Frontiers in Reproduction Pioneer Award, 2017<\/p>\n

UConn Health Dean\u2019s Award for Excellence in Research Mentoring, 2018<\/p>\n

 <\/p>\n

RECENT OTHER PROFESSIONAL ACTIVITIES<\/u>:<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
1983 – present<\/td>\nFaculty for summer courses at the Marine Biological Lab (Woods Hole)<\/p>\n

(Embryology, Frontiers in Reproduction)<\/span><\/td>\n<\/tr>\n

1986 – 2007<\/td>\nAssociate editor, Developmental Biology<\/u><\/td>\n<\/tr>\n
2007 – present<\/td>\nEditorial board, Developmental Biology<\/u><\/td>\n<\/tr>\n
1998 – 2012<\/td>\nNIH study sections (member: Cell Development and Function, 1998-2002; Cellular, Molecular, and Integrative Reproduction, 2006-2012)<\/td>\n<\/tr>\n
2011- 2016<\/td>\nNICHD Board of scientific counselors<\/td>\n<\/tr>\n
2000 – present<\/td>\nMBL Committee on Courses (Woods Hole) (chair since 2012)<\/td>\n<\/tr>\n
2012<\/td>\nCo-organizer, 2012 Cold Spring Harbor meeting on Germ Cells<\/td>\n<\/tr>\n
2017 – 2019<\/td>\nCo-organizer, 5th<\/sup> International Oocyte Meeting<\/td>\n<\/tr>\n
2017 – 2022<\/td>\nScientific Advisory Board, Max Planck Institute for Biophysical Chemistry<\/td>\n<\/tr>\n
2018 – 2021<\/td>\nScientific Advisory Council, Frontiers in Reproduction Program (Burroughs Welcome Fund)<\/td>\n<\/tr>\n
2019 – 2024<\/td>\nScientific Advisory Board, Villefranche-sur-Mer Developmental Biology Laboratory (Sorbonne Universit\u00e9 \u2013 CNRS)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

INVITED PRESENTATIONS (2005-2019)<\/u>:<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
March, 2005<\/td>\nSeminar at University of Connecticut, Storrs<\/td>\n<\/tr>\n
March, 2005<\/td>\nEuropean Molecular Biology Organization, conference on “Meiotic Divisions and Checkpoints” (Corsica, France)<\/td>\n<\/tr>\n
July, 2005<\/td>\nNICHD workshop on”Gamete Interaction”<\/td>\n<\/tr>\n
July, 2005<\/td>\nGordon Conference on “Fertilization and the Activation of Development”<\/td>\n<\/tr>\n
November, 2005<\/td>\nSeminar at Boston College<\/td>\n<\/tr>\n
April, 2006<\/td>\nSeminar at University of Pennsylvania<\/td>\n<\/tr>\n
May, 2006<\/td>\nSeminar at Northwestern University<\/td>\n<\/tr>\n
June, 2006<\/td>\nGordon Conference on “Mammalian Gametogenesis and Embryogenesis”<\/td>\n<\/tr>\n
June, 2006<\/td>\nEndocrine Society Meeting, symposium talk<\/td>\n<\/tr>\n
November, 2006<\/td>\nSymposium on “Cell Signaling in Gamete Activation: from Basic Research to ART” (Tokyo, Japan)<\/td>\n<\/tr>\n
November, 2006<\/td>\nSeminar at Tokyo Institute of Technology<\/td>\n<\/tr>\n
February, 2007<\/td>\nSeminar at Florida Institute of Technology<\/td>\n<\/tr>\n
February, 2007<\/td>\nSeminar at University of Florida, Whitney Lab<\/td>\n<\/tr>\n
July, 2007<\/td>\nSeminar at Marine Biological Lab, Woods Hole<\/td>\n<\/tr>\n
March, 2008<\/td>\nSeminar at the Fred Hutchinson Cancer Research Center, Seattle WA<\/td>\n<\/tr>\n
October, 2008<\/td>\nSeminar at the Vollum Institute, Portland OR<\/td>\n<\/tr>\n
April, 2009<\/td>\nSeminar at Ottawa Health Research Institute, Ottawa, Canada<\/td>\n<\/tr>\n
June, 2009<\/td>\nConference on “Meiotic Divisions in Oocytes” (Tourtour, France)<\/td>\n<\/tr>\n
June, 2009<\/td>\nSeminar at the European Molecular Biology Laboratory, Heidelberg, Germany<\/td>\n<\/tr>\n
July, 2009<\/td>\nSeminar at University of Wuerzburg, Germany<\/td>\n<\/tr>\n
July, 2009<\/td>\nGordon Conference on “Cell Fusion”<\/td>\n<\/tr>\n
November, 2009<\/td>\nKeynote speaker for “R\u00e9seau Qu\u00e9b\u00e9cois en R\u00e9production” Symposium, Montreal<\/td>\n<\/tr>\n
March, 2010<\/td>\nSeminar at University of Pennsylvania<\/td>\n<\/tr>\n
June, 2010<\/td>\nJean Clark Dan Symposium, Woods Hole<\/td>\n<\/tr>\n
September, 2010<\/td>\nKeynote speaker for meeting on \u201cMechanisms of Egg Maturation and Fertilization\u201d, University of Washington, Friday Harbor Labs<\/td>\n<\/tr>\n
October, 2010<\/td>\nCold Spring Harbor meeting on Germ Cells<\/td>\n<\/tr>\n
December, 2010<\/td>\nSeminar at University of Massachusetts, Amherst<\/td>\n<\/tr>\n
March, 2011<\/td>\nSeminar at University of Massachusetts, Worcester<\/td>\n<\/tr>\n
June, 2011<\/td>\nSeminar at University of Minnesota, Minneapolis<\/td>\n<\/tr>\n
December, 2011<\/td>\nSpeaker at meeting of American Society for Cell Biology<\/td>\n<\/tr>\n
April 2012<\/td>\nSeminar at National Institute of Environmental Health Sciences, North Carolina<\/td>\n<\/tr>\n
June 2012<\/td>\nSpeaker at NICHD Intramural Scientific Retreat, Bethesda<\/td>\n<\/tr>\n
February, 2013<\/td>\nSeminar at Washington State University<\/td>\n<\/tr>\n
April, 2013<\/td>\nSeminar at Cornell University<\/td>\n<\/tr>\n
June, 2013<\/td>\nSpeaker at EMBO conference on \u201cOocyte Maturation and Fertilization\u201d<\/td>\n<\/tr>\n
June, 2013<\/td>\nSeminar at University of Giessen, Germany<\/td>\n<\/tr>\n
November, 2013<\/td>\nSeminar at Connecticut Children\u2019s Hospital<\/td>\n<\/tr>\n
March, 2014<\/td>\nSeminar at University of Connecticut, Storrs<\/td>\n<\/tr>\n
March, 2015<\/td>\nSeminar at University of Washington, Seattle<\/td>\n<\/tr>\n
June, 2015<\/td>\nSpeaker at conference on \u201cOocyte Maturation and Fertilization\u201d, Japan<\/td>\n<\/tr>\n
February, 2016<\/td>\nSeminar at University of Pittsburgh<\/td>\n<\/tr>\n
November, 2016<\/td>\nSeminar at University of Minnesota<\/td>\n<\/tr>\n
June, 2017<\/td>\nKeynote speaker for Frontiers in Reproduction Symposium, Woods Hole<\/td>\n<\/tr>\n
June, 2017<\/td>\n\u00a08th<\/sup> International Conference on cGMP, Germany<\/td>\n<\/tr>\n
July, 2017<\/td>\nGordon Conference on “Fertilization and the Activation of Development”<\/td>\n<\/tr>\n
April, 2018<\/td>\nSeminar at the European Molecular Biology Laboratory, Heidelberg, Germany<\/td>\n<\/tr>\n
April, 2018<\/td>\n117th<\/sup> International Titisee Conference, From Oocyte to Embryo, Germany<\/td>\n<\/tr>\n
April, 2018<\/td>\nSeminar at University of Hamburg, Germany<\/td>\n<\/tr>\n
July, 2018<\/td>\nSpeaker at meeting of the Society for the Study of Reproduction<\/td>\n<\/tr>\n
January, 2019<\/td>\nSeminar at Imagine Institute, Paris, France<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

RECENT FUNDING<\/u>:<\/p>\n\n\n\n\n\n\n
1981- 2024<\/td>\nNIH, R01\/R37-HD14939, “Signal Transduction at Fertilization”<\/td>\n<\/tr>\n
2000-2004<\/td>\nHuman Frontiers Science Program, \u201cSignal Transduction during Oocyte Maturation\u201d<\/td>\n<\/tr>\n
2005-2010<\/td>\nNIH, R01-DK073499, “Regulation of meiotic arrest by a Gs<\/sub>-linked receptor”<\/td>\n<\/tr>\n
2010- 2013<\/td>\nNIH, R21HD067017, \u201cFunction of a voltage-sensitive phosphatase in the regulation of sperm-egg fusion\u201d<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

PUBLICATIONS:<\/u><\/p>\n

Jaffe, L.A., Weisenseel, M.H. and Jaffe, L.F. (1975).\u00a0 Calcium accumulations within the growing tips of pollen tubes.\u00a0 J. Cell Biol<\/u>. 67: 488-492.<\/p>\n

Jaffe, L.A. (1976). Fast block to polyspermy in sea urchin eggs is electrically mediated. Nature<\/u> 261:68\u201171.<\/p>\n

Jaffe, L.A. and Robinson, K.R. (1978).\u00a0 Membrane potential of the unfertilized sea urchin egg.\u00a0 Develop. Biol<\/u>. 62: 215-228.<\/p>\n

Jaffe, L.A., Hagiwara, S. and Kado, R.T. (1978).\u00a0 The time course of cortical vesicle fusion in sea urchin eggs observed as membrane capacitance changes.\u00a0 Develop. Biol<\/u>. 67: 243-248.<\/p>\n

Jaffe, L.A., Gould-Somero, M. and Holland, L. (1979).\u00a0 Ionic mechanism of the fertilization potential of the marine worm, Urechis caupo<\/em> (Echiura).\u00a0 J. Gen. Physiol<\/u>. 73: 469-492.<\/p>\n

Gould-Somero, M., Jaffe, L.A. and Holland, L.Z. (1979).\u00a0 Electrically-mediated fast polyspermy block in eggs of the marine worm, Urechis caupo<\/em>.\u00a0 J. Cell Biol<\/u>. 82: 426-440.<\/p>\n

Hagiwara, S. and Jaffe, L.A. (1979).\u00a0 Electrical properties of egg cell membranes.\u00a0 Ann. Rev. Biophys. Bioeng<\/u>. 8: 385-416.<\/p>\n

Jaffe, L.A. (1980).\u00a0 Electrical polyspermy block in sea urchins.\u00a0 Nicotine and low sodium experiments.\u00a0 Develop. Growth. Differ<\/u>. 22: 503-507.<\/p>\n

Tilney, L.G. and Jaffe, L.A. (1980).\u00a0 Actin, microvilli, and the fertilization cone of sea urchin eggs.\u00a0 J.\u00a0Cell Biol<\/u>. 87: 771-782.<\/p>\n

Jaffe, L.A. and Guerrier, P. (1981).\u00a0 Localization of electrical excitability in the early embryo of Dentalium<\/em>.\u00a0 Develop. Biol<\/u>. 83: 370-373.<\/p>\n

Jaffe, L.A., Gould-Somero, M. and Holland, L.Z. (1982).\u00a0 Studies of the mechanism of the electrical polyspermy block using voltage clamp during cross-species fertilization.\u00a0 J. Cell Biol<\/u>.\u00a0 92: 616-621.<\/p>\n

Jaffe, L.A., Sharp, A.P. and Wolf, D.W. (1983).\u00a0 Absence of an electrical polyspermy block in the mouse.\u00a0 Develop. Biol<\/u>. 96: 317-323.<\/p>\n

Jaffe, L.A. (1983).\u00a0 Fertilization potentials from eggs of the marine worms Chaetopterus<\/em> and Saccoglossus<\/em>.\u00a0 In The Physiology of Excitable Cells<\/u>, eds. W.J. Moody and A.D. Grinnell.\u00a0 Alan R. Liss, New York, pp.\u00a0211-218.<\/p>\n

Jaffe, L.A., Cross, N.L. and Picheral, B. (1983). \u00a0Studies of the voltage-dependent polyspermy block using cross-species fertilization of amphibians.\u00a0 Develop. Biol<\/u>. 98: 319-326.<\/p>\n

Jaffe, L.A. and Cross, N.L. (1984).\u00a0 Electrical properties of vertebrate oocyte membranes.\u00a0 Biol. Reprod<\/u>. 30: 50-54.<\/p>\n

Gould-Somero, M. and Jaffe, L.A. (1984).\u00a0 Control of cell fusion at fertilization by membrane potential.\u00a0 In Cell Fusion: Gene Transfer and Transformation<\/u>, eds.\u00a0R.F. Beers, Jr. and E.G. Bassett.\u00a0 Raven Press, New\u00a0York, pp. 27-38.<\/p>\n

Turner, P.R., Sheetz, M.P. and Jaffe, L.A. (1984).\u00a0 Fertilization increases the polyphosphoinositide content of sea urchin eggs.\u00a0 Nature<\/u> 310: 414-415.<\/p>\n

Jaffe, L.A. and Schlichter, L.C. (1985).\u00a0 Fertilization-induced ionic conductances in eggs of the frog, Rana pipiens<\/em>.\u00a0 J. Physiol<\/u>. 358: 299\u2011319.<\/p>\n

Jaffe, L.A., Kado, R.T. and Muncy, L. (1985).\u00a0 Propagating potassium and chloride conductances during activation and fertilization of the egg of the frog,\u00a0 Rana pipiens<\/em>.\u00a0 J.\u00a0Physiol<\/u>. 368: 227-242.<\/p>\n

Jaffe, L.A. and Gould, M. (1985).\u00a0 Polyspermy prevention mechanisms.\u00a0 In Biology of Fertilization<\/u>, vol. 3, ed. C.B. Metz and A. Monroy.\u00a0 Academic Press, New York, pp. 223\u2011250.<\/p>\n

Kline, D., Jaffe, L.A. and Tucker, R.P. (1985).\u00a0 Fertilization potential and polyspermy prevention in the egg of the nemertean, Cerebratulus lacteus.<\/em>\u00a0 J.\u00a0Exp. Zool<\/u>. 236: 45-52.<\/p>\n

Turner, P.R., Jaffe, L.A. and Fein, A. (1986).\u00a0 Regulation of cortical vesicle exocytosis in sea urchin eggs by inositol 1,4,5-trisphosphate and GTP-binding protein.\u00a0 J. Cell Biol<\/u>. 102: 70-76.<\/p>\n

Jaffe, L.A. and Cross, N.L. (1986).\u00a0 Electrical regulation of sperm egg fusion.\u00a0 Ann. Rev. Physiol<\/u>. 48: 191-200.<\/p>\n

Jaffe, L.A., Kado, R.T. and Kline, D. (1986).\u00a0 A calcium-activated sodium conductance produces a long-duration action potential in the egg of a nemertean worm.\u00a0 J.\u00a0Physiol<\/u>. 381: 263-278.<\/p>\n

Kline, D., Jaffe, L.A. and Kado, R.T. (1986).\u00a0 A calcium-activated sodium conductance contributes to the fertilization potential in the egg of the nemertean worm Cerebratulus lacteus<\/em>. Develop. Biol<\/u>. 117: 184\u2011193.<\/p>\n

Turner, P.R., Jaffe, L.A. and Primakoff, P. (1987).\u00a0 A cholera toxin-sensitive G\u2011protein stimulates exocytosis in sea urchin eggs.\u00a0 Develop. Biol<\/u>. 120: 577-583.<\/p>\n

Kline, D., Simoncini, L., Mandel, G., Maue, R., Kado, R.T. and Jaffe, L.A. (1988).\u00a0 Fertilization events induced by neurotransmitters after injection of mRNA in Xenopus<\/em>\u00a0 eggs.\u00a0 Science<\/u> 241: 464-467.<\/p>\n

Jaffe, L.A., Turner, P.R., Kline, D., Kado, R.T. and Shilling, F. (1988).\u00a0 G\u2011proteins and egg activation.\u00a0 Cell Differentiation and Development<\/u> 25: 15-18.<\/p>\n

Turner, P.R. and Jaffe, L.A. (1989).\u00a0 G\u2011proteins and the regulation of oocyte maturation and fertilization.\u00a0 In The Cell Biology of Fertilization<\/u>, eds. H.\u00a0Schatten and G.\u00a0Schatten.\u00a0 Academic Press, Orlando, pp.\u00a0297-318.<\/p>\n

Jaffe, L.A. (1989).\u00a0 Receptors, G-proteins, and egg activation.\u00a0 In\u00a0 Mechanisms of Egg Activation<\/u>, eds. R. Nuccitelli, G.N. Cherr and W.H. Clark, Jr.\u00a0 Plenum Press, N.Y., pp. 151-155.<\/p>\n

Shilling, F., Chiba, K., Hoshi, M., Kishimoto, T. and Jaffe, L.A. (1989).\u00a0 Pertussis toxin inhibits 1\u2011methyladenine-induced maturation in starfish oocytes.\u00a0 Develop. Biol<\/u>. 133: 605-608.<\/p>\n

Iwao, Y. and Jaffe, L.A. (1989).\u00a0 Evidence that the voltage-dependent component in the fertilization process is contributed by the sperm.\u00a0 Develop. Biol<\/u>. 134: 446-451.<\/p>\n

Shilling, F., Mandel, G. and Jaffe, L.A. (1990).\u00a0 Activation by serotonin of starfish eggs expressing the rat serotonin 1c receptor.\u00a0 Cell Regulation<\/u> (now called Molecular Biology of the Cell)<\/u> 1: 465-469.<\/p>\n

Chiba, K., Kado, R.T. and Jaffe, L.A. (1990).\u00a0 Development of calcium release mechanisms during starfish oocyte maturation.\u00a0 Develop. Biol<\/u>. 140: 300-306.<\/p>\n

Kline, D.,\u00a0 Kado, R.T., Kopf, G.S., and Jaffe, L.A. (1990).\u00a0 Receptors, G-proteins, and activation of the amphibian egg.\u00a0 In \u201cMechanisms of Fertilization\u201d (B. Dale, ed.), NATO ASI Series, volume H45, 529-541.\u00a0 Springer-Verlag, Berlin.<\/p>\n

Jaffe, L.A. (1990).\u00a0 First messengers at fertilization.\u00a0 J. Reprod. Fert<\/u>., supplement 42: 107-116.<\/p>\n

Kline, D., Kopf, G.S.,\u00a0 Muncy, L.F. and Jaffe, L.A. (1991).\u00a0 Evidence for the involvement of a pertussis toxin-insensitive G-protein in egg activation of the frog, Xenopus laevis<\/em>.\u00a0 Develop. Biol<\/u>.\u00a0 143: 218-229.<\/p>\n

Terasaki, M., and Jaffe, L.A. (1991).\u00a0 Organization of the sea urchin egg endoplasmic reticulum and its reorganization at fertilization.\u00a0 J. Cell Biol.<\/u> 114: 929-940.<\/p>\n

Jaffe, L.A. and Terasaki, M. (1993).\u00a0 Structural changes of the endoplasmic reticulum of sea urchin eggs during fertilization.\u00a0 Develop. Biol<\/u>. 156: 566-573.<\/p>\n

Jaffe, L.A., Gallo, C.J., Lee, R.H., Ho, Y.K., and Jones, T.L.Z. (1993).\u00a0 Oocyte maturation in starfish is mediated by the bg-subunit complex of a G-protein.\u00a0 J. Cell. Biol<\/u>. 121: 775-783.<\/p>\n

Terasaki, M., and Jaffe, L.A. (1993).\u00a0 Imaging the endoplasmic reticulum in living sea urchin eggs.\u00a0 Meth. Cell Biol<\/u>. 38: 211-220.<\/p>\n

Jaffe, L.A., and Terasaki, M. (1993).\u00a0 Egg activation at fertilization:\u00a0 structural changes in the endoplasmic reticulum.\u00a0 In \u201cMeiosis II: Contemporary Approaches to the Study of Meiosis,\u201d\u00a0 F. P. Haseltine and S. Heyner, eds.,\u00a0 AAAS Press, Washington, D.C., pp. 167-174.<\/p>\n

Jaffe, L.A. (1993). The experimental process: the electrical polyspermy block. Essay in the textbook Molecular and Cellular Biology<\/u>, by Stephen L. Wolfe. Wadsworth Publishing Co., pp. 1110-1111.<\/p>\n

Shilling, F.M., Carroll, D.J.,\u00a0 Muslin, A.J., Escobedo, J.A., Williams, L.T., and Jaffe, L.A. (1994).\u00a0 Evidence for both tyrosine kinase and G-protein coupled pathways leading to starfish egg activation.\u00a0 Develop. Biol.<\/u> 162: 590-599.<\/p>\n

Jaffe, L.A., and Terasaki, M. (1994).\u00a0 Structural changes in the endoplasmic reticulum of starfish oocytes during meiotic maturation and fertilization.\u00a0 Develop.\u00a0 Biol.<\/u> 164: 579-587.<\/p>\n

Gallo, C. J., Hand, A. R., Jones, T. L. Z., and Jaffe, L. A. (1995).\u00a0 Stimulation of Xenopus<\/em> oocyte maturation by inhibition of the G-protein as\u00a0subunit, a component of the plasma membrane and yolk platelet membranes.\u00a0 J. Cell Biol.<\/u> 130: 275-284.<\/p>\n

Mehlmann, L. M., Terasaki, M., Jaffe, L. A., and Kline, D. (1995).\u00a0 Reorganization of the endoplasmic reticulum during meiotic maturation of the mouse oocyte.\u00a0 Develop. Biol.<\/u> 170: 607-615.<\/p>\n

Carroll, D. J., and Jaffe, L. A. (1995).\u00a0 Proteases stimulate fertilization-like responses in starfish eggs.\u00a0 Develop. Biol.<\/u> 170: 690-700.<\/p>\n

Jaffe, L.A. (1996). Egg membranes during fertilization.\u00a0 In “Molecular Biology of Membrane Transport Disorders,” S.G.Schultz, T. Andreoli, A. Brown, D. Fambrough, J. Hoffman, and M. Welsh, eds.\u00a0 Plenum Publishing Corp., New York, ch. 18, pp. 367-378.<\/p>\n

Gallo, C.J., Jones, T.L.Z., Aragay, A.M., and Jaffe, L.A. (1996).\u00a0 Increased expression of Gaq\u00a0family G-proteins during oocyte maturation and early development of Xenopus laevis<\/em>.\u00a0 Develop. Biol.<\/u> 177: 300-308.<\/p>\n

Terasaki, M., Jaffe, L.A., Hunnicutt, G.R., and Hammer, J.A. III. (1996).\u00a0 Structural change of the endoplasmic reticulum during fertilization:\u00a0 evidence for loss of membrane continuity using the green fluorescent protein.\u00a0 Develop. Biol.<\/u> 179: 320-328.<\/p>\n

Carroll, D.J., Ramarao, C.S., Mehlmann, L.M., Roche, S., Terasaki, M., and Jaffe, L.A. (1997).\u00a0 Calcium release at fertilization in starfish eggs is mediated by phospholipase Cg.\u00a0 J. Cell Biol. <\/u>138: 1303-1311.<\/p>\n

Williams, C.J., Mehlmann, L.M., Jaffe, L.A., Kopf, G.S., and Schultz, R.M. (1998).\u00a0 Evidence that Gq\u00a0family G proteins do not function in mouse egg activation at fertilization.\u00a0 Develop. Biol.<\/u> 198: 116-127.<\/p>\n

Mehlmann, L.M., Carpenter, G., Rhee, S.G., and Jaffe. L.A. (1998).\u00a0 SH2 domain-mediated activation of phospholipase Cg is not required to initiate Ca2+\u00a0release at fertilization of mouse eggs.\u00a0 Develop. Biol.<\/u> 203: 221-232.<\/p>\n

Carroll, D.J., Albay, D.T., Terasaki, M., Jaffe, L.A., and Foltz, K.R. (1999).\u00a0 Identification of PLCg-dependent and independent events during fertilization of sea urchin eggs.\u00a0 Develop. Biol.<\/u> 206: 232-247.<\/p>\n

Giusti, A.F., Carroll, D.J., Abassi, Y.A., Terasaki, M., Foltz, K.R., and Jaffe, L.A. (1999).\u00a0 Requirement of a Src family kinase for initiating calcium release at fertilization in starfish eggs.\u00a0 J. Biol. Chem.<\/u> 274:\u00a0 29318-29322.<\/p>\n

Runft, L.L., Watras, J., and Jaffe, L.A. (1999).\u00a0 Calcium release at fertilization of Xenopus<\/em> eggs requires type I IP3\u00a0receptors, but not SH2 domain-mediated activation of PLCg or Gq-mediated activation of PLCb.\u00a0 Develop. Biol.<\/u> 214: 399-411.<\/p>\n

Giusti, A.F., Xu, W., Hinkle, B., Terasaki, M., and Jaffe, L.A. (2000).\u00a0 Evidence that fertilization activates starfish eggs by sequential activation of a Src-like kinase and phospholipase Cg.\u00a0 J. Biol. Chem.<\/u> 275: 16788-16794<\/p>\n

Runft, L.L., and Jaffe, L.A. (2000).\u00a0 Sperm extract injection into ascidian eggs signals Ca2+<\/sup> release by the same pathway as fertilization.\u00a0 Development<\/u> 127: 3227-3236.<\/p>\n

Jaffe, L.A., Giusti, A.F., Carroll, D.J., and Foltz, K.R. (2001).\u00a0 Ca2+<\/sup> signalling during fertilization of echinoderm eggs. \u00a0Sem. Cell Develop. Biol.<\/u> 12: 45-51.<\/p>\n

Mehlmann, L.M., Chattopadhyay, A., Carpenter, G., and Jaffe, L.A. (2001).\u00a0 Evidence that phospholipase C from the sperm is not responsible for initiating Ca2+<\/sup> release in mouse eggs at fertilization.\u00a0 Develop. Biol.<\/u> 236: 492-501.<\/p>\n

Runft, L.L., Jaffe, L.A., and Mehlmann, L.M. (2002).\u00a0 Egg activation at fertilization: where it all begins.\u00a0 Develop. Biol.<\/u> 245: 237-254.<\/p>\n

Mehlmann, L.M., Jones, T.L.Z., and Jaffe, L.A. (2002).\u00a0 Meiotic arrest in the mouse follicle maintained by a Gs<\/sub> protein in the oocyte.\u00a0 Science<\/u> 297: 1343-1345.<\/p>\n

Kalinowski, R.R., Jaffe, L.A., Foltz, K.R., and Giusti, A.F. (2003).\u00a0 A receptor linked to a Gi<\/sub>-family G-protein functions in initiating oocyte maturation in starfish but not frogs.\u00a0 Develop. Biol.<\/u> 253: 139-149.<\/p>\n

Giusti, A.F., O’Neill, F.J., Yamasu, K., Foltz, K.R., and Jaffe, L.A. (2003).\u00a0 Function of a sea urchin Src family kinase in initiating Ca2+<\/sup> release at fertilization.\u00a0 Develop. Biol.<\/u> 256: 367-378.<\/p>\n

Kalinowski, R.R., Berlot, C.H., Jones, T.L.Z., Ross, L.F., Jaffe, L.A., and Mehlmann, L.M. (2004).\u00a0 Maintenance of meiotic prophase arrest in vertebrate oocytes by a Gs<\/sub> protein-mediated pathway.\u00a0 Develop. Biol.<\/u> 267: 1-13.<\/p>\n

Jaffe, L.A., and Terasaki, M. (2004).\u00a0 Quantitative microinjection of oocytes, eggs, and embryos.\u00a0 Meth. Cell Biol.<\/em><\/u> 74: 219-242.<\/p>\n

Terasaki, M., and Jaffe, L.A. (2004).\u00a0 Labeling of cell membranes and compartments for live cell fluorescence microscopy.\u00a0 Meth. Cell Biol.<\/u> 74: 469-489.<\/p>\n

Mehlmann, L.M., Saeki, Y., Tanaka, S., Brennan, T.J., Evsikov, A.V., Pendola, F.L., Knowles, B.B., Eppig, J.J., and Jaffe, L.A. (2004).\u00a0 The Gs<\/sub>-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.\u00a0 Science<\/u> 306: 1947-1950.<\/p>\n

Mehlmann, L.M., and Jaffe, L.A. (2005).\u00a0 SH2 domain-mediated activation of an SRC family kinase is not required to initiate Ca2+<\/sup> release at fertilization in mouse eggs.\u00a0 Reproduction<\/u> 129: 557-564.<\/p>\n

Freudzon, L., Norris, R.P., Hand, A.R., Tanaka, S., Saeki, Y., Jones, T.L.Z., Rasenick, M.M., Berlot, C.H., Mehlmann, L.M., and Jaffe, L.A. (2005).\u00a0 Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs<\/sub> G protein.\u00a0 J. Cell Biol.<\/u> 171: 255-265.<\/p>\n

Mehlmann, L.M., Kalinowski, R.R., Ross, L.F., Parlow, A.F., Hewlett, E.L., and Jaffe, L.A. (2006).\u00a0 Meiotic resumption in response to luteinizing hormone is independent of a Gi<\/sub> family G protein or calcium in the mouse oocyte.\u00a0 Develop. Biol.<\/u> 299: 345-355.<\/p>\n

Norris, R.P., Freudzon, L., Freudzon, M., Hand, A.R., Mehlmann, L.M., and Jaffe, L.A. (2007).\u00a0 A Gs<\/sub>-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-Gs<\/sub> signaling.\u00a0 Develop. Biol.<\/u> 310:240-249.<\/p>\n

Norris, R.P., Freudzon, M., Mehlmann, L.M., Cowan, A.E., Simon, A.M., Paul, D.L., Lampe, P.D., and Jaffe, L.A. (2008). Luteinizing hormone causes MAPK-dependent phosphorylation and closure of Cx43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption. Development<\/u> 135:3229-3238.<\/p>\n

Jaffe, L.A., Norris, R.P., Freudzon, M., Ratzan, W.J., and Mehlmann, L.M. (2009). Microinjection of follicle-enclosed mouse oocytes.\u00a0 Methods Mol. Biol.<\/u> 518:157-173.<\/p>\n

Norris, R.P., Ratzan, W.J., Freudzon, M., Mehlmann, L.M., Krall, J., Movsesian, M.A., Wang, H., Ke, H., Nikolaev, V.O., and Jaffe, L.A. (2009). Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development<\/u> 136:1869-1878.<\/p>\n

Jaffe, L.A., and Norris, R.P. (2010). Initiation of the meiotic prophase-to-metaphase transition in mammalian oocytes. In Oogenesis — The Universal Process<\/u>, ed. M.-H. Verlhac and A. Villeneuve. John Wiley & Sons, Ltd, London, pp. 181-197.<\/p>\n

Norris, R.P., Freudzon, M., Nikolaev, V.O., and Jaffe, L.A. (2010). EGF receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to luteinizing hormone. Reproduction<\/u> 140: 655-662.<\/p>\n

Ratzan, W.J., Evsikov, A.V., Okamura, Y., and Jaffe, L.A. (2011). Voltage sensitive phosphoinositide phosphatases of Xenopus<\/em>: their tissue distribution and voltage dependence. J. Cell. Physiol.<\/u> 226: 2740-2746.<\/p>\n

Robinson, J.W., Zhang, M., Shuhaibar, L.C., Norris, R.P., Geerts, A., Wunder, F., Eppig, J.J., Potter, L.R., and Jaffe, L.A. (2012). Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes. Develop. Biol.<\/u> 366: 308-316.<\/p>\n

Lee, K.-B., Zhang, M., Sugiura, K., Wigglesworth, K., Uliasz, T., Jaffe, L.A., and Eppig, J.J. (2013). Hormonal coordination of natriuretic peptide type C and natriuretic peptide receptor 3 expression in mouse granulosa cells. Biol. Reprod.<\/u> 88: 42, 1-9.<\/p>\n

Egbert, J.R., Shuhaibar, L.C., Edmund, A.B., Van Helden, D.A., Robinson, J.W., Uliasz, T.F., Baena, V., Geerts, A., Wunder, F., Potter, L.R., and Jaffe, L.A. (2014). Dephosphorylation and inactivation of the NPR2 guanylyl cyclase in the granulosa cells contributes to the LH-induced cGMP decrease that causes meiotic resumption in rat oocytes. Development<\/u> 141: 3594-3604.<\/p>\n

Shuhaibar, L.C., Egbert, J.R., Norris, R.P., Lampe, P.D., Nikolaev, V.O., Thunemann, M., Wen, L., Feil, R., and Jaffe, L.A. (2015). Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc. Natl. Acad. Sci. USA<\/u> 112: 5527-5532.<\/p>\n

Shuhaibar, L.C., Egbert, J.R., Edmund, A.B., Uliasz, T.F., Dickey, D.M., Yee, S.-P., Potter, L.R., and Jaffe, L.A. (2016) Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone. Develop. Biol.<\/u> 409:194-201.<\/p>\n

Egbert J.R., Uliasz T.F., Shuhaibar, L.C., Geerts A., Wunder F., Kleiman R.J., Humphrey J.M., Lampe P.D., Artemyev, N.O., Rybalkin, S.D., Beavo, J.A., Movsesian, M.A., and Jaffe, L.A. (2016). Luteinizing hormone causes phosphorylation and activation of the cyclic GMP phosphodiesterase PDE5 in rat ovarian follicles, contributing, together with PDE1 activity, to the resumption of meiosis. Biol. Reprod.<\/u> 94(5):110.<\/p>\n

Jaffe, L.A., and Egbert J.R. (2017). Regulation of mammalian oocyte meiosis by intercellular communication within the ovarian follicle. Ann. Rev. Physiol.<\/u> 79:237-260.<\/p>\n

Robinson, J.W., Egbert, J.R., Davydova, J., Schmidt, H., Jaffe, L.A., and Potter, L.R. (2017). Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B. Cellular Signaling<\/u> 40:222-229.<\/p>\n

Shuhaibar, L.C., Robinson, J.W., Vigone, G., Shuhaibar, N.P., Egbert, J.R., Baena, V., Uliasz, T.V., Kaback, D., Yee, S.-P., Feil, R., Fisher, M.C., Dealy, C.N., Potter, L.R., and Jaffe, LA. (2017). Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor. eLife<\/u> 6:e31343.<\/p>\n

Egbert, J.R., Yee, S.-P., and Jaffe, L.A. (2018). Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis. Develop. Biol.<\/u> 435:6-14.<\/p>\n

Jaffe, L.A. (2018). Shedding light on spawning in jellyfish. eLife<\/u> 7:e34258.<\/p>\n

Vigone G., Shuhaibar L.C., Egbert, J.R., Uliasz, T.F., Movsesian, M.A., and Jaffe, L.A. (2018). Multiple cAMP phosphodiesterases act together to prevent premature oocyte meiosis and ovulation. Endocrinology <\/u>5:2142-2152.<\/p>\n

Shuhaibar, L.C., Carroll, D.J., and Jaffe, L.A. (2018). Preparing for fertilization: Intercellular signals for oocyte maturation. In “Reproductive and Developmental Strategies” (K. Kobayashi, T. Kitano, Y. Iwao, and M. Kondo, eds), Springer, Japan, chapter 25, pp. 535-548.<\/p>\n

Jaffe, L.A. (2018). The fast block to polyspermy: New insight into a century old problem. J. Gen. Physiol.<\/u> 150:1233-1234.<\/p>\n

Egbert, J.R., Fahey, P.G., Reimer, J., Owen, C.M., Evsikov, A.V., Nikolaev, V.O., Griesbeck, O., Ray, R.S., Tolias, A.S., and Jaffe, L.A. (2019). Follicle-stimulating hormone and luteinizing hormone increase Ca2+<\/sup> in the granulosa cells of mouse ovarian follicles. Biol. Reprod.<\/u> 101:433-444.<\/p>\n","protected":false},"excerpt":{"rendered":"

  ADDRESS: Department of Cell Biology University of Connecticut Health Center Farmington, CT 06030 USA Phone:\u00a0 (860)\u00a0 679-2661 e-mail:\u00a0\u00a0 ljaffe@uchc.edu BIRTH: January 9, 1952, Pasadena, CA EDUCATION: University of Wisconsin, Madison, WI 1969-1971 Purdue University, W. Lafayette, IN B.S. (biology) 1971-1973 University of California, Los Angeles, CA Ph.D. (biology; advisor: Susumu Hagiwara) 1974-1977 Marine Biological […]<\/p>\n","protected":false},"author":305,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-27 17:48:28","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/1582"}],"collection":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/users\/305"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/comments?post=1582"}],"version-history":[{"count":4,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/1582\/revisions"}],"predecessor-version":[{"id":1594,"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/pages\/1582\/revisions\/1594"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/cell-biology\/wp-json\/wp\/v2\/media?parent=1582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}