Jitendra K. Kanaujiya

Jitendra Kanaujiya Instructor (In Residence)
Department of Cell Biology

CONTACT

Phone: 860-679-2775
Email: kanaujiya@uchc.edu
Office: E5038

 

UConn Health, School of Medicine
263 Farmington Avenue, Farmington, CT 06030

 

Research interests

  • Apply regenerative medicine to develop personalized therapeutic options for hematopoietic diseases.
  • Understand the cross talk between human hematopoietic niche cells and hematopoietic cells during hemogenic endothelial to hematopoietic transition using human induced pluripotent stem cells.

In Dr. Oguro’s lab, my research focuses on generating hematopoietic stem cells (HSCs) from human induced pluripotent stem cells (iPSCs). HSC transplantation is widely used in clinics to treat blood disorders and malignancies. However, there is limited availability of suitable donors and current clinical HSC collection protocols do not always produce enough number of HSCs from donors to ensure transplantation success. Thus, there is a strong demand for an alternative source of autologous HSCs for clinical transplantation. A promising source for a virtually unlimited supply of HSCs is the in vitro differentiation of human iPSCs into HSCs. However, the derivation of HSCs from human iPSCs in culture remains elusive. To fill this gap, we are developing methods to generate autologous HSCs from human iPSCs by mimicking the environment during the developmental process of HSCs (Figure 1). Additionally, I am exploring the role of estrogen receptor α signaling in HSC proliferation and mobilization.

Figure 1.

Poster Presentations

JK Kanaujiya, EG Lingenheld, WC Skarnes and H Oguro. Inhibition of P53-mediated apoptosis promotes hematopoietic differentiation of human pluripotent stem cell-derived hemogenic endothelial cells. The International Society of Stem Cell Research (ISSCR) 2020 Virtual Annual Meeting.

J Kanaujiya, J Balsbaugh, E Reichenberger, I Chen. Whole-cell proteomic profiling of osteoclasts from a mouse model for craniometaphyseal dysplasia. The American Society for Bone and Mineral Research (ASBMR) 2018 Annual Meeting at Montréal, Québec, Canada. Journal of Bone and Mineral Research, 33, 183-184.
 

Selected publications