{"id":15,"date":"2017-04-28T12:41:24","date_gmt":"2017-04-28T16:41:24","guid":{"rendered":"https:\/\/health.uconn.edu\/bezsonova-lab\/?page_id=15"},"modified":"2025-06-24T17:16:00","modified_gmt":"2025-06-24T21:16:00","slug":"publications","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/bezsonova-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div id=\"pl-15\"  class=\"panel-layout\" ><div id=\"pg-15-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-15-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-15-0-0-0\" class=\"so-panel widget widget_metaslider_widget panel-first-child\" data-index=\"0\" ><div id=\"metaslider-id-759\" style=\"max-width: 1000px; margin: 0 auto;\" class=\"ml-slider-3-80-0 ml-slider-pro-2-36-0 metaslider metaslider-flex metaslider-759 ml-slider ms-theme-default nav-hidden\" role=\"region\" aria-roledescription=\"Slideshow\" aria-label=\"publications\">\n    <div id=\"metaslider_container_759\">\n        <div id=\"metaslider_759\">\n            <ul class='slides'>\n                <li style=\"display: block; width: 100%;\" class=\"slide-1017 ms-image \" aria-roledescription=\"slide\" aria-label=\"slide-1017\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-content\/uploads\/sites\/114\/2024\/03\/covers-1000x350.jpg\" height=\"350\" width=\"1000\" alt=\"\" class=\"slider-759 slide-1017\" title=\"covers\" \/><\/li>\n            <\/ul>\n        <\/div>\n        \n    <\/div>\n<\/div><\/div><div id=\"panel-15-0-0-1\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><div>\n<div class=\"citation-wrap\">\n<div class=\"citation\">\n<ol>\n<li>\n<div class=\"ncbi-docsum\"><span class=\"authors\">Korchak E, Geddes-Buehre D, Bezsonova I.<span>\u00a0<\/span><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40532929\/\">The C-Terminal Tail of Ubiquitin-Specific Protease 7 Facilitates Ubiquitin Release and Ensures Efficient Catalytic Turnover.<span>\u00a0<\/span><\/a><span class=\"source\">J Mol Biol<\/span>.<span>\u00a0<\/span><span class=\"pubdate\">2025 Jun 16;<\/span><span class=\"pages\">:169298<\/span><span>.\u00a0<\/span><span class=\"doi\">doi: 10.1016\/j.jmb.2025.169298.<span>\u00a0<\/span><\/span><span class=\"pubstatus\">[Epub ahead of print]<span>\u00a0<\/span><\/span><span class=\"pmid\">PubMed PMID: 40532929<\/span><span>.<\/span><\/div>\n<\/li>\n<li><span class=\"authors\">Valles GJ, Korchak EJ, Geddes-Buehre DH, Jaiswal N, Korzhnev DM, Bezsonova I.<span>\u00a0<\/span><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40397674\/\">Activation dynamics of ubiquitin-specific protease 7.<span>\u00a0<\/span><\/a><span class=\"source\">Proc Natl Acad Sci U S A<\/span><span>.\u00a0<\/span><span class=\"pubdate\">2025 May 27;<\/span><span class=\"volume\">122<\/span><span class=\"issue\">(21)<\/span><span class=\"pages\">:e2426632122<\/span><span>.\u00a0<\/span><span class=\"doi\">doi: 10.1073\/pnas.2426632122.<span>\u00a0<\/span><\/span><span class=\"pubstatus\">Epub 2025 May 21.<span>\u00a0<\/span><\/span><span class=\"pmid\">PubMed PMID: 40397674<\/span><span>.<\/span><\/li>\n<li><span class=\"authors\">Korchak EJ, Sharafi M, Maisonet IJ, Caro P, Schaaf CP, Buhrlage SJ, Bezsonova I.<span>\u00a0<\/span><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40166258\/\">Functional Spectrum of USP7 Pathogenic Variants in Hao-Fountain Syndrome: Insights into the Enzyme's Activity, Stability, and Allosteric Modulation.<span>\u00a0<\/span><\/a><span class=\"source\">bioRxiv<\/span><span>.\u00a0<\/span><span class=\"pubdate\">2025 Mar 20;<\/span><span>.\u00a0<\/span><span class=\"doi\">doi: 10.1101\/2025.03.20.644318.<span>\u00a0<\/span><\/span><span class=\"pmid\">PubMed PMID: 40166258<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC11957113<\/span><span>.<\/span><\/li>\n<li><span class=\"authors\">Jaen Maisonet I, Sharafi M, Korchak EJ, Salazar-Chaparro A, Bratt A, Parikh T, Varca AC, Shah B, Darnowski M, Chung M, Teh WP, Che J, Bezsonova I, Buhrlage SJ.<span>\u00a0<\/span><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40161813\/\">Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7).<span>\u00a0<\/span><\/a><span class=\"source\">bioRxiv<\/span><span>.\u00a0<\/span><span class=\"pubdate\">2025 Mar 16;<\/span><span>.\u00a0<\/span><span class=\"doi\">doi: 10.1101\/2025.03.14.643379.<span>\u00a0<\/span><\/span><span class=\"pmid\">PubMed PMID: 40161813<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC11952563<\/span><span>.<\/span><\/li>\n<li><span class=\"authors\">Bregnard TA, Fairchild D, Chen X, Erlandsen H, Tarasov SG, Walters KJ, Korzhnev DM, Bezsonova I.<span>\u00a0<\/span><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39742997\/\">Differences in structure, dynamics, and zinc coordination between isoforms of human ubiquitin ligase UBE3A.<span>\u00a0<\/span><\/a><span class=\"source\">J Biol Chem<\/span><span>.\u00a0<\/span><span class=\"pubdate\">2025 Feb;<\/span><span class=\"volume\">301<\/span><span class=\"issue\">(2)<\/span><span class=\"pages\">:108149<\/span><span>.\u00a0<\/span><span class=\"doi\">doi: 10.1016\/j.jbc.2024.108149.<span>\u00a0<\/span><\/span><span class=\"pubstatus\">Epub 2024 Dec 30.<span>\u00a0<\/span><\/span><span class=\"pmid\">PubMed PMID: 39742997<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC11795592<\/span><span>.<\/span><\/li>\n<li><span class=\"authors\">Moreno NC, Korchak EJ, Latancia MT, D'Orlando DA, Adegbenro T, Bezsonova I, Woodgate R, Ashton NW.<span>\u00a0<\/span><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39416117\/\">DNA polymerase \u03b7 is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation.<span>\u00a0<\/span><\/a><span class=\"source\">bioRxiv<\/span><span>.\u00a0<\/span><span class=\"pubdate\">2024 Oct 13;<\/span><span>.\u00a0<\/span><span class=\"doi\">doi: 10.1101\/2024.10.12.618026.<span>\u00a0<\/span><\/span><span class=\"pmid\">PubMed PMID: 39416117<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC11482926<\/span><span>.<\/span><\/li>\n<li><span class=\"authors\">Ashton NW, Jaiswal N, Moreno NC, Semenova IV, D'Orlando DA, Latancia MT, McIntyre J, Woodgate R, Bezsonova I.<span>\u00a0<\/span><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37935254\/\">A Novel Interaction Between RAD23A\/B and Y-family DNA Polymerases.<span>\u00a0<\/span><\/a><span class=\"source\">J Mol Biol<\/span>.<span>\u00a0<\/span><span class=\"pubdate\">2023 Dec 15;<\/span><span class=\"volume\">435<\/span><span class=\"issue\">(24)<\/span><span class=\"pages\">:168353<\/span><span>.\u00a0<\/span><span class=\"doi\">doi: 10.1016\/j.jmb.2023.168353.<span>\u00a0<\/span><\/span><span class=\"pubstatus\">Epub 2023 Nov 5.<span>\u00a0<\/span><\/span><span class=\"pmid\">PubMed PMID: 37935254<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC10842004<\/span><span>. <\/span><\/li>\n<li>Bregnard TA, Fairchild D, Erlandsen H, Semenova IV, Szczepaniak R, Ahmed A, Weller SK, Korzhnev DM, Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37473756\/\">Conformational exchange at a C(2)H(2) zinc-binding site facilitates redox sensing by the PML protein.\u00a0<\/a><span class=\"source\">Structure<\/span>.\u00a0<span class=\"pubdate\">2023 Sep 7;<\/span><span class=\"volume\">31<\/span><span class=\"issue\">(9)<\/span><span class=\"pages\">:1086-1099.e6<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.str.2023.06.014.\u00a0<\/span><span class=\"pubstatus\">Epub 2023 Jul 19.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 37473756<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC10528520<\/span>.<\/li>\n<li>Valles G, Pozhidaeva A, Korzhnev DM, Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35536398\/\">Backbone and ILV side-chain NMR resonance assignments of the catalytic domain of human deubiquitinating enzyme USP7.\u00a0<\/a><span class=\"source\">Biomol NMR Assign<\/span>.\u00a0<span class=\"pubdate\">2022 Oct;<\/span><span class=\"volume\">16<\/span><span class=\"issue\">(2)<\/span><span class=\"pages\">:197-203<\/span>.\u00a0<span class=\"doi\">doi: 10.1007\/s12104-022-10079-2.\u00a0<\/span><span class=\"pubstatus\">Epub 2022 May 10.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 35536398<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC9529858<\/span>.<\/li>\n<li>Bregnard T, Ahmed A, Semenova IV, Weller SK, Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35667129\/\">The B-box1 domain of PML mediates SUMO E2-E3 complex formation through an atypical interaction with UBC9.\u00a0<\/a><span class=\"source\">Biophys Chem<\/span>.\u00a0<span class=\"pubdate\">2022 Aug;<\/span><span class=\"volume\">287<\/span><span class=\"pages\">:106827<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.bpc.2022.106827.\u00a0<\/span><span class=\"pubstatus\">Epub 2022 May 18.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 35667129<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC9491232<\/span>.<\/li>\n<li>Dusek CO, Dash RC, McPherson KS, Calhoun JT, Bezsonova I, Korzhnev DM, Hadden MK.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35608245\/\">DNA Sequence Specificity Reveals a Role of the HLTF HIRAN Domain in the Recognition of Trinucleotide Repeats.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2022 May 24;<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/acs.biochem.2c00027.\u00a0<\/span><span class=\"pubstatus\">[Epub ahead of print]\u00a0<\/span><span class=\"pmid\">PubMed PMID: 35608245<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC9684356<\/span>.<\/li>\n<li>Mahdi S, Bezsonova I, Beuning PJ, Korzhnev DM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33761093\/\">NMR resonance assignments for the nucleotide binding domains of the E. coli clamp loader complex \u03b3 subunit.\u00a0<\/a><span class=\"source\">Biomol NMR Assign<\/span>.\u00a0<span class=\"pubdate\">2021 Oct;<\/span><span class=\"volume\">15<\/span><span class=\"issue\">(2)<\/span><span class=\"pages\">:281-285<\/span>.\u00a0<span class=\"doi\">doi: 10.1007\/s12104-021-10018-7.\u00a0<\/span><span class=\"pubstatus\">Epub 2021 Mar 24.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 33761093<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC8460709<\/span>.<\/li>\n<li>McPherson KS, Zaino AM, Dash RC, Rizzo AA, Li Y, Hao B, Bezsonova I, Hadden MK, Korzhnev DM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33314657\/\">Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis.\u00a0<\/a><span class=\"source\">ChemMedChem<\/span>.\u00a0<span class=\"pubdate\">2021 Apr 8;<\/span><span class=\"volume\">16<\/span><span class=\"issue\">(7)<\/span><span class=\"pages\">:1126-1132<\/span>.\u00a0<span class=\"doi\">doi: 10.1002\/cmdc.202000893.\u00a0<\/span><span class=\"pubstatus\">Epub 2021 Jan 28.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 33314657<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC8035318<\/span>.<\/li>\n<li>Valles GJ, Ashton NW, Jaiswal N, Woodgate R, Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33437851\/\">Nuclear magnetic resonance spectral data of the USP7 TRAF and UBL1-2 domains in complex with DNA polymerase \u03b9 peptides.\u00a0<\/a><span class=\"source\">Data Brief<\/span>.\u00a0<span class=\"pubdate\">2021 Feb;<\/span><span class=\"volume\">34<\/span><span class=\"pages\">:106680<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.dib.2020.106680.\u00a0<\/span><span class=\"pubstatus\">eCollection 2021 Feb.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 33437851<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC7788100<\/span>.<\/li>\n<li>Ashton NW, Valles GJ, Jaiswal N, Bezsonova I, Woodgate R.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33279577\/\">DNA Polymerase \u03b9 Interacts with Both the TRAF-like and UBL1-2 Domains of USP7.\u00a0<\/a><span class=\"source\">J Mol Biol<\/span>.\u00a0<span class=\"pubdate\">2021 Jan 22;<\/span><span class=\"volume\">433<\/span><span class=\"issue\">(2)<\/span><span class=\"pages\">:166733<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.jmb.2020.166733.\u00a0<\/span><span class=\"pubstatus\">Epub 2020 Dec 3.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 33279577<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC7873624<\/span>.<\/li>\n<li>Valles GJ, Bezsonova I, Woodgate R, Ashton NW.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32850836\/\">USP7 Is a Master Regulator of Genome Stability.\u00a0<\/a><span class=\"source\">Front Cell Dev Biol<\/span>.\u00a0<span class=\"pubdate\">2020;<\/span><span class=\"volume\">8<\/span><span class=\"pages\">:717<\/span>.\u00a0<span class=\"doi\">doi: 10.3389\/fcell.2020.00717.\u00a0<\/span><span class=\"pubstatus\">eCollection 2020.\u00a0<\/span><span class=\"pubtype\">Review.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 32850836<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC7419626<\/span>.<\/li>\n<li>Adlakha M, Livingston CM, Bezsonova I, Weller SK.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31748398\/\">The Herpes Simplex Virus 1 Immediate Early Protein ICP22 Is a Functional Mimic of a Cellular J Protein.\u00a0<\/a><span class=\"source\">J Virol<\/span>.\u00a0<span class=\"pubdate\">2020 Jan 31;<\/span><span class=\"volume\">94<\/span><span class=\"issue\">(4)<\/span>.\u00a0<span class=\"doi\">doi: 10.1128\/JVI.01564-19.\u00a0<\/span><span class=\"pubstatus\">Print 2020 Jan 31.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 31748398<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC6997750<\/span>.<\/li>\n<li>Pozhidaeva A, Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30807924\/\">USP7: Structure, substrate specificity, and inhibition.\u00a0<\/a><span class=\"source\">DNA Repair (Amst)<\/span>.\u00a0<span class=\"pubdate\">2019 Apr;<\/span><span class=\"volume\">76<\/span><span class=\"pages\">:30-39<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.dnarep.2019.02.005.\u00a0<\/span><span class=\"pubstatus\">Epub 2019 Feb 16.\u00a0<\/span><span class=\"pubtype\">Review.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 30807924<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC6481172<\/span>.<\/li>\n<li>Machado LESF, De Paula VS, Pustovalova Y, Bezsonova I, Valente AP, Korzhnev DM, Almeida FCL.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30207151\/\">Conformational Dynamics of a Cysteine-Stabilized Plant Defensin Reveals an Evolutionary Mechanism to Expose Hydrophobic Residues.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2018 Oct 9;<\/span><span class=\"volume\">57<\/span><span class=\"issue\">(40)<\/span><span class=\"pages\">:5797-5806<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/acs.biochem.8b00753.\u00a0<\/span><span class=\"pubstatus\">Epub 2018 Sep 24.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 30207151<\/span>.<\/li>\n<li>Kumar S, Caimano MJ, Anand A, Dey A, Hawley KL, LeDoyt ME, La Vake CJ, Cruz AR, Ramirez LG, Pa\u0161t\u011bkov\u00e1 L, Bezsonova I, \u0160majs D, Salazar JC, Radolf JD.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29895642\/\">Sequence Variation of Rare Outer Membrane Protein \u03b2-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete.\u00a0<\/a><span class=\"source\">mBio<\/span>.\u00a0<span class=\"pubdate\">2018 Jun 12;<\/span><span class=\"volume\">9<\/span><span class=\"issue\">(3)<\/span>.\u00a0<span class=\"doi\">doi: 10.1128\/mBio.01006-18.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 29895642<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC6016234<\/span>.<\/li>\n<li>Zambrello MA, Schuyler AD, Maciejewski MW, Delaglio F, Bezsonova I, Hoch JC.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29522805\/\">Nonuniform sampling in multidimensional NMR for improving spectral sensitivity.\u00a0<\/a><span class=\"source\">Methods<\/span>.\u00a0<span class=\"pubdate\">2018 Apr 1;<\/span><span class=\"volume\">138-139<\/span><span class=\"pages\">:62-68<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.ymeth.2018.03.001.\u00a0<\/span><span class=\"pubstatus\">Epub 2018 Mar 6.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 29522805<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC5984134<\/span>.<\/li>\n<li>Pozhidaeva A, Valles G, Wang F, Wu J, Sterner DE, Nguyen P, Weinstock J, Kumar KGS, Kanyo J, Wright D, Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29056420\/\">USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.\u00a0<\/a><span class=\"source\">Cell Chem Biol<\/span>.\u00a0<span class=\"pubdate\">2017 Dec 21;<\/span><span class=\"volume\">24<\/span><span class=\"issue\">(12)<\/span><span class=\"pages\">:1501-1512.e5<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.chembiol.2017.09.004.\u00a0<\/span><span class=\"pubstatus\">Epub 2017 Oct 19.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 29056420<\/span>.<\/li>\n<li>Groshong AM, Dey A, Bezsonova I, Caimano MJ, Radolf JD.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29259089\/\">Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter.\u00a0<\/a><span class=\"source\">mBio<\/span>.\u00a0<span class=\"pubdate\">2017 Dec 19;<\/span><span class=\"volume\">8<\/span><span class=\"issue\">(6)<\/span>.\u00a0<span class=\"doi\">doi: 10.1128\/mBio.02047-17.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 29259089<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC5736914<\/span>.<\/li>\n<li>Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29236775\/\">Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60.\u00a0<\/a><span class=\"source\">PLoS One<\/span>.\u00a0<span class=\"pubdate\">2017;<\/span><span class=\"volume\">12<\/span><span class=\"issue\">(12)<\/span><span class=\"pages\">:e0189744<\/span>.\u00a0<span class=\"doi\">doi: 10.1371\/journal.pone.0189744.\u00a0<\/span><span class=\"pubstatus\">eCollection 2017.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 29236775<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC5728538<\/span>.<\/li>\n<li>Korzhnev DM, Neculai D, Dhe-Paganon S, Arrowsmith CH, Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27771863\/\">Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2\/SNF2 DNA damage tolerance proteins.\u00a0<\/a><span class=\"source\">J Biomol NMR<\/span>.\u00a0<span class=\"pubdate\">2016 Nov;<\/span><span class=\"volume\">66<\/span><span class=\"issue\">(3)<\/span><span class=\"pages\">:209-219<\/span>.\u00a0<span class=\"doi\">doi: 10.1007\/s10858-016-0070-9.\u00a0<\/span><span class=\"pubstatus\">Epub 2016 Oct 22.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 27771863<\/span>.<\/li>\n<li>Pozhidaeva AK, Mohni KN, Dhe-Paganon S, Arrowsmith CH, Weller SK, Korzhnev DM, Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26224631\/\">Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1.\u00a0<\/a><span class=\"source\">J Biol Chem<\/span>.\u00a0<span class=\"pubdate\">2015 Sep 18;<\/span><span class=\"volume\">290<\/span><span class=\"issue\">(38)<\/span><span class=\"pages\">:22907-18<\/span>.\u00a0<span class=\"doi\">doi: 10.1074\/jbc.M115.664805.\u00a0<\/span><span class=\"pubstatus\">Epub 2015 Jul 29.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 26224631<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC4645603<\/span>.<\/li>\n<li>Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26051180\/\">HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.\u00a0<\/a><span class=\"source\">Mol Cell<\/span>.\u00a0<span class=\"pubdate\">2015 Jun 18;<\/span><span class=\"volume\">58<\/span><span class=\"issue\">(6)<\/span><span class=\"pages\">:1090-100<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.molcel.2015.05.013.\u00a0<\/span><span class=\"pubstatus\">Epub 2015 Jun 4.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 26051180<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC4475461<\/span>.<\/li>\n<li>Rizzo AA, Salerno PE, Bezsonova I, Korzhnev DM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25162118\/\">NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2014 Sep 23;<\/span><span class=\"volume\">53<\/span><span class=\"issue\">(37)<\/span><span class=\"pages\">:5895-906<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/bi500823h.\u00a0<\/span><span class=\"pubstatus\">Epub 2014 Sep 15.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 25162118<\/span>.<\/li>\n<li>Bezsonova I.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24727478\/\">Solution NMR structure of the DNA-binding domain from Scml2 (sex comb on midleg-like 2).\u00a0<\/a><span class=\"source\">J Biol Chem<\/span>.\u00a0<span class=\"pubdate\">2014 May 30;<\/span><span class=\"volume\">289<\/span><span class=\"issue\">(22)<\/span><span class=\"pages\">:15739-49<\/span>.\u00a0<span class=\"doi\">doi: 10.1074\/jbc.M113.524009.\u00a0<\/span><span class=\"pubstatus\">Epub 2014 Apr 10.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 24727478<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC4140928<\/span>.<\/li>\n<li>Machado LE, Pustovalova Y, Kile AC, Pozhidaeva A, Cimprich KA, Almeida FC, Bezsonova I, Korzhnev DM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23907177\/\">PHD domain from human SHPRH.\u00a0<\/a><span class=\"source\">J Biomol NMR<\/span>.\u00a0<span class=\"pubdate\">2013 Aug;<\/span><span class=\"volume\">56<\/span><span class=\"issue\">(4)<\/span><span class=\"pages\">:393-9<\/span>.\u00a0<span class=\"doi\">doi: 10.1007\/s10858-013-9758-2.\u00a0<\/span><span class=\"pubstatus\">Epub 2013 Aug 2.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 23907177<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC3905319<\/span>.<\/li>\n<li>Bezsonova I, Rujan I, Bobenchik AM, Gorbatyuk V, Maciejewski MW, Gorbatyuk O, Hao B, Arthanari H, Mamoun CB, Hoch JC.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22392340\/\">(1)H, (13)C, and (15)N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum.\u00a0<\/a><span class=\"source\">Biomol NMR Assign<\/span>.\u00a0<span class=\"pubdate\">2013 Apr;<\/span><span class=\"volume\">7<\/span><span class=\"issue\">(1)<\/span><span class=\"pages\">:17-20<\/span>.\u00a0<span class=\"doi\">doi: 10.1007\/s12104-012-9372-3.\u00a0<\/span><span class=\"pubstatus\">Epub 2012 Mar 6.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 22392340<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC3882757<\/span>.<\/li>\n<li>Pustovalova Y, Bezsonova I, Korzhnev DM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22828282\/\">The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase \u03b7 and Rev7 subunit of polymerase \u03b6.\u00a0<\/a><span class=\"source\">FEBS Lett<\/span>.\u00a0<span class=\"pubdate\">2012 Sep 21;<\/span><span class=\"volume\">586<\/span><span class=\"issue\">(19)<\/span><span class=\"pages\">:3051-6<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.febslet.2012.07.021.\u00a0<\/span><span class=\"pubstatus\">Epub 2012 Jul 22.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 22828282<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC3572780<\/span>.<\/li>\n<li>Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, G\u00fcnther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, W\u00fcthrich K, Yokoyama S.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22955930\/\">In support of the BMRB.\u00a0<\/a><span class=\"source\">Nat Struct Mol Biol<\/span>.\u00a0<span class=\"pubdate\">2012 Sep;<\/span><span class=\"volume\">19<\/span><span class=\"issue\">(9)<\/span><span class=\"pages\">:854-60<\/span>.\u00a0<span class=\"doi\">doi: 10.1038\/nsmb.2371.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 22955930<\/span>.<\/li>\n<li>Pozhidaeva A, Pustovalova Y, D'Souza S, Bezsonova I, Walker GC, Korzhnev DM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22691049\/\">NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase \u03b7.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2012 Jul 10;<\/span><span class=\"volume\">51<\/span><span class=\"issue\">(27)<\/span><span class=\"pages\">:5506-20<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/bi300566z.\u00a0<\/span><span class=\"pubstatus\">Epub 2012 Jun 28.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 22691049<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC3732116<\/span>.<\/li>\n<li>Lemak A, Yee A, Bezsonova I, Dhe-Paganon S, Arrowsmith CH.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21947926\/\">Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.\u00a0<\/a><span class=\"source\">J Biomol NMR<\/span>.\u00a0<span class=\"pubdate\">2011 Sep;<\/span><span class=\"volume\">51<\/span><span class=\"issue\">(1-2)<\/span><span class=\"pages\">:185-90<\/span>.\u00a0<span class=\"doi\">doi: 10.1007\/s10858-011-9552-y.\u00a0<\/span><span class=\"pubstatus\">Epub 2011 Sep 27.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 21947926<\/span>.<\/li>\n<li>Bezsonova I, Walker JR, Bacik JP, Duan S, Dhe-Paganon S, Arrowsmith CH.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19791798\/\">Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2009 Nov 10;<\/span><span class=\"volume\">48<\/span><span class=\"issue\">(44)<\/span><span class=\"pages\">:10542-8<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/bi901131u.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 19791798<\/span>.<\/li>\n<li>Korzhnev DM, Bezsonova I, Lee S, Chalikian TV, Kay LE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19111555\/\">Alternate binding modes for a ubiquitin-SH3 domain interaction studied by NMR spectroscopy.\u00a0<\/a><span class=\"source\">J Mol Biol<\/span>.\u00a0<span class=\"pubdate\">2009 Feb 20;<\/span><span class=\"volume\">386<\/span><span class=\"issue\">(2)<\/span><span class=\"pages\">:391-405<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.jmb.2008.11.055.\u00a0<\/span><span class=\"pubstatus\">Epub 2008 Dec 6.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 19111555<\/span>.<\/li>\n<li>Bezsonova I, Bruce MC, Wiesner S, Lin H, Rotin D, Forman-Kay JD.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18680311\/\">Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2008 Aug 26;<\/span><span class=\"volume\">47<\/span><span class=\"issue\">(34)<\/span><span class=\"pages\">:8937-49<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/bi800439t.\u00a0<\/span><span class=\"pubstatus\">Epub 2008 Aug 5.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 18680311<\/span>.<\/li>\n<li>Bezsonova I, Forman-Kay JD, Prosser RS.\u00a0<span class=\"title\">Molecular oxygen as a paramagnetic NMR probe of protein solvent exposure and topology.\u00a0<\/span><span class=\"journalname\">Concepts in Magnetic Resonance Part A.\u00a0<\/span><span class=\"displaydate\">2008 July<\/span>;\u00a0<span class=\"volume\">32A<\/span><span class=\"issue\">(4)<\/span><span class=\"page\">:239<\/span>.\u00a0<span class=\"doi\">doi: 0.1002\/cmr.a.20118.<\/span><\/li>\n<li>Lundstr\u00f6m P, Teilum K, Carstensen T, Bezsonova I, Wiesner S, Hansen DF, Religa TL, Akke M, Kay LE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17554498\/\">Fractional 13C enrichment of isolated carbons using [1-13C]- or [2- 13C]-glucose facilitates the accurate measurement of dynamics at backbone Calpha and side-chain methyl positions in proteins.\u00a0<\/a><span class=\"source\">J Biomol NMR<\/span>.\u00a0<span class=\"pubdate\">2007 Jul;<\/span><span class=\"volume\">38<\/span><span class=\"issue\">(3)<\/span><span class=\"pages\">:199-212<\/span>.\u00a0<span class=\"doi\">doi: 10.1007\/s10858-007-9158-6.\u00a0<\/span><span class=\"pubstatus\">Epub 2007 Jun 7.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 17554498<\/span>.<\/li>\n<li>Bezsonova I, Evanics F, Marsh JA, Forman-Kay JD, Prosser RS.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17253684\/\">Oxygen as a paramagnetic probe of clustering and solvent exposure in folded and unfolded states of an SH3 domain.\u00a0<\/a><span class=\"source\">J Am Chem Soc<\/span>.\u00a0<span class=\"pubdate\">2007 Feb 14;<\/span><span class=\"volume\">129<\/span><span class=\"issue\">(6)<\/span><span class=\"pages\">:1826-35<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/ja065173o.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 17253684<\/span>.<\/li>\n<li>Evanics F, Kitevski JL, Bezsonova I, Forman-Kay J, Prosser RS.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17182189\/\">19F NMR studies of solvent exposure and peptide binding to an SH3 domain.\u00a0<\/a><span class=\"source\">Biochim Biophys Acta<\/span>.\u00a0<span class=\"pubdate\">2007 Feb;<\/span><span class=\"volume\">1770<\/span><span class=\"issue\">(2)<\/span><span class=\"pages\">:221-30<\/span>.\u00a0<span class=\"doi\">doi: 10.1016\/j.bbagen.2006.10.017.\u00a0<\/span><span class=\"pubstatus\">Epub 2006 Nov 11.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 17182189<\/span>.<\/li>\n<li>Evanics F, Bezsonova I, Marsh J, Kitevski JL, Forman-Kay JD, Prosser RS.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17115707\/\">Tryptophan solvent exposure in folded and unfolded states of an SH3 domain by 19F and 1H NMR.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2006 Nov 28;<\/span><span class=\"volume\">45<\/span><span class=\"issue\">(47)<\/span><span class=\"pages\">:14120-8<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/bi061389r.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 17115707<\/span>.<\/li>\n<li>Korzhnev DM, Bezsonova I, Evanics F, Taulier N, Zhou Z, Bai Y, Chalikian TV, Prosser RS, Kay LE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16608362\/\">Probing the transition state ensemble of a protein folding reaction by pressure-dependent NMR relaxation dispersion.\u00a0<\/a><span class=\"source\">J Am Chem Soc<\/span>.\u00a0<span class=\"pubdate\">2006 Apr 19;<\/span><span class=\"volume\">128<\/span><span class=\"issue\">(15)<\/span><span class=\"pages\">:5262-9<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/ja0601540.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 16608362<\/span>.<\/li>\n<li>Bezsonova I, Korzhnev DM, Prosser RS, Forman-Kay JD, Kay LE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16605239\/\">Hydration and packing along the folding pathway of SH3 domains by pressure-dependent NMR.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2006 Apr 18;<\/span><span class=\"volume\">45<\/span><span class=\"issue\">(15)<\/span><span class=\"pages\">:4711-9<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/bi060177r.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 16605239<\/span>.<\/li>\n<li>Bezsonova I, Singer A, Choy WY, Tollinger M, Forman-Kay JD.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16300404\/\">Structural comparison of the unstable drkN SH3 domain and a stable mutant.\u00a0<\/a><span class=\"source\">Biochemistry<\/span>.\u00a0<span class=\"pubdate\">2005 Nov 29;<\/span><span class=\"volume\">44<\/span><span class=\"issue\">(47)<\/span><span class=\"pages\">:15550-60<\/span>.\u00a0<span class=\"doi\">doi: 10.1021\/bi0512795.\u00a0<\/span><span class=\"pmid\">PubMed PMID: 16300404<\/span>.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Korchak E, Geddes-Buehre D, Bezsonova I.\u00a0The C-Terminal Tail of Ubiquitin-Specific Protease 7 Facilitates Ubiquitin Release and Ensures Efficient Catalytic Turnover.\u00a0J Mol Biol.\u00a02025 Jun 16;:169298.\u00a0doi: 10.1016\/j.jmb.2025.169298.\u00a0[Epub ahead of print]\u00a0PubMed PMID: 40532929. Valles GJ, Korchak EJ, Geddes-Buehre DH, Jaiswal N, Korzhnev DM, Bezsonova I.\u00a0Activation dynamics of ubiquitin-specific protease 7.\u00a0Proc Natl Acad Sci U S A.\u00a02025 May 27;122(21):e2426632122.\u00a0doi: [&hellip;]<\/p>\n","protected":false},"author":39,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-13 02:29:14","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-json\/wp\/v2\/pages\/15"}],"collection":[{"href":"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-json\/wp\/v2\/users\/39"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":12,"href":"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":1101,"href":"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-json\/wp\/v2\/pages\/15\/revisions\/1101"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/bezsonova-lab\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}