Drug Delivery

The presence of drugs, such as growth factors and synthetic small molecules, is an important aspect of tissue regeneration. The efficient administration of such agents aid in the activation of specific cell pathways that lead to proliferation, differentiation, and recruitment of cells to the injured or diseased site. However, due to the body’s renal systems, drugs are rapidly cleared from circulation, sometimes before they are able to fully affect their targeted sites. To combat this issue, drugs are generally administered in high dosages, but at times cause detrimental side effects systemically. Further, certain drugs may cause as much or more harm than good if administered systemically, and would be far more effective if it were possible to deliver them locally to the region of interest. Thus, the conjugation or encapsulation of such agents with or within drug delivery vehicles is an elegant method to overcome the aforementioned issues. Such vehicles permit the efficient delivery of factors to a targeted site, controlled release of factors at the site, and sustained level of drug over a predetermined time period.

cells on microspheres