Journal Articles

• AI is a viable alternative to high throughput screening: a 318-target study. *Ephraim F. Trakhtenberg is a member of the program
  Atomwise AIMS Program*. Scientific reports, 2024; 14(1):7526.
• Nfe2l3 promotes neuroprotection and long-distance axon regeneration after injury in vivo. Issue Cover Page article. *Corresponding author.
  Lukomska, A.; Frost, M.P.; Theune, W.C.; Xing, J.; Gupta, M.; and Trakhtenberg, E.F*. Experimental Neurology, 2024; 375:114741
• Upregulation of developmentally-downregulated miR-1247-5p promotes neuroprotection and axon regeneration in vivo. *Corresponding author.
  Lukomska, A.; Theune, W.C.; Frost, M.P.; Xing, J.; Kearney, A.; and Trakhtenberg, E.F*. Neuroscience Letters, 2024; 823:137662
• Experimental upregulation of developmentally downregulated ribosomal protein large subunits 7 and 7A promotes axon regeneration after injury in vivo. *Corresponding author.
  Xing, J.; Theune, W.C.; Lukomska, A.; Frost, M.P.; Damania, A.; and Trakhtenberg, E.F*. Experimental Neurology, 2023; 368:114510
• Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. *Trakhtenberg, E.F., is a member of the RReSTORe Consortium.
  Soucy, J.R., Johnson, T.V. *RReSTORe Consortium, et al. Molecular Neurodegeneration, 2023; 18(1):64
• Premature axon-oligodendrocyte interaction contributes to stalling of experimental axon regeneration after injury to the white matter. *Corresponding author.
  Trakhtenberg, E.F*. Neural Regeneration Research, 2023; 19(3):469-470
• CellTools algorithm for mapping scRNA-seq query cells to the reference dataset improves the classification of resilient and susceptible retinal ganglion cell types. *Corresponding author.
  Rheaume, B.A.; Xing, J.; Theune, W.C.; DeRosa, S.G.; and Trakhtenberg, E.F*. bioRxiv, 2023; Jun 19:464552
• Transcriptomic profiling of retinal cells reveals a subpopulation of microglia/macrophages expressing Rbpms marker of retinal ganglion cells (RGCs) that confound identification of RGCs. *Corresponding author.
  Theune, W.C.; Frost, M.P.; and Trakhtenberg, E.F*. Brain Research, 2023; 1811:148377
• The people behind the papers – Jian Xing, Agnieszka Lukomska, Bruce Rheaume and Ephraim Trakhtenberg.
  The Company of Biologists. Development, 2023; 150(8):dev201870
• Experimental gene expression of developmentally downregulated Crmp1, Crmp4, and Crmp5 promotes axon regeneration and retinal ganglion cell survival after optic nerve injury. *Corresponding author.
  Lukomska, A.; Theune, W.C.; Xing, J.; Frost, M.P.; Damania, A.; Gupta, M.; and Trakhtenberg, E.F*. Brain Research, 2023; 1809:148368
• Pten inhibition dedifferentiates long-distance axon-regenerating intrinsically photosensitive retinal ganglion cells and upregulates mitochondria-associated Dynlt1a and Lars2. *Corresponding author.
  Rheaume, B.A.; Xing, J.; Lukomska, A.; Theune, W.C.; Damania, A.; Sjogren, G.; and Trakhtenberg, E.F*. Development, 2023; 150(8):dev.201644
• Post-injury born oligodendrocytes incorporate into the glial scar and contribute to the inhibition of axon regeneration. *Corresponding author.
  Xing, J.; Lukomska, A.; Rheaume, B.A.; Kim, J.; Sajid, M.S.; Damania, A.; and Trakhtenberg, E.F*. Development, 2023; 150(8):dev.201311
• Developmentally upregulated Transcriptional Elongation Factor A like 3 suppresses axon regeneration after optic nerve injury. *Corresponding author.
  Lukomska, A.; Kim, J.; Rheaume, B.A.; Xing, J.; Hoyt, A.; Lecky, E.; Damania, A.; Steidl, T.; and Trakhtenberg, E.F*. Neuroscience Letters, 2021; 765(20):136260
• Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers.
  Bargagna-Mohan, P., Schultz, G., Rheaume, B.A., Trakhtenberg, E.F., Robson, P., Pal-Ghosh, S., Stepp, M.A., Given, K.S., Macklin, W.B., and Mohan, R. J Neurosci Res, 2020; 99(3):731-749
• Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes. *Corresponding author.
  Rheaume, Bruce A; Jereen, Amyeo; Bolisetty, Mohan; Sajid, Muhammad S; Yang, Yue; Renna, Kathleen; Sun, Lili; Robson, Paul; and Trakhtenberg, Ephraim F*. Nature Communications, 2018; 9(2759)
• The extent of extra-axonal tissue damage determines the levels of CSPG upregulation and the success of experimental axon regeneration in the CNS. *Corresponding author.
  Kim, Juhwan; Sajid, Muhammad S; and Trakhtenberg, Ephraim F*. Scientific Reports, 2018; 8(1):9839
• Zinc chelation and Klf9 knockdown cooperatively promote axon regeneration after optic nerve injury. *Corresponding author.
  Trakhtenberg, Ephraim F*; Li, Yiqing; Feng, Qian; Janice, Tso; Rosenberg, Paul A; Goldberg, Jeffrey L; and Benowitz, Larry I. Experimental Neurology, 2017; 300:22-29
• Cell types differ in global coordination of splicing and proportion of highly expressed genes. *Corresponding author.
  Trakhtenberg, Ephraim F*; Pho, Nam; Holton, Kristina M; Chittenden, Thomas W; Goldberg, Jeffrey L; and Dong, Lingsheng. Scientific Reports, 2016; 6:32249
• Serotonin receptor 2C regulates neurite growth and is necessary for normal retinal processing of visual information. *Co-corresponding author.
  Trakhtenberg, Ephraim F*; Pita-Thomas, Wolfgang; Fernandez, Stephanie G; Patel, Karan H; Venugopalan, Praseeda; Shechter, Jesse M; Morkin, Melina I; Galvao, Joana; Liu, Xiongfei; Dombrowski, Susan M; and Goldberg, Jeffrey L*. Developmental Neurobiology, 2016; 77(4):419-437
• The N-terminal Set-β Protein Isoform Induces Neuronal Death. *Co-corresponding author.
  Trakhtenberg, Ephraim F*; Morkin, Melina I; Patel, Karan H; Fernandez, Stephanie G; Sang, Alan; Shaw, Peter; Liu, Xiongfei; Wang, Yan; Mlacker, Gregory M; Gao, Han; Velmeshev, Dmitry; Dombrowski, Susan M; Vitek, Michael P; and Goldberg, Jeffrey L*. The Journal of Biological Chemistry, 2015; 290(21):13417-26
• Inflammation and Optic Nerve Regeneration
  Andereggen, L., Trakhtenberg, E. F., Yuqin, Y., and Benowitz, L. I. Neuroinflammation: New Insights into Beneficial and Detrimental Functions, 2015; 189-204
• Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones.
  Steketee, Michael B; Oboudiyat, Carly; Daneman, Richard; Trakhtenberg, Ephraim F; Lamoureux, Philip; Weinstein, Jessica E; Heidemann, Steve; Barres, Ben A; and Goldberg, Jeffrey L. Investigative Ophthalmology & Visual Science, 2014; 55(7):4369-77
• Regulating Set-β's Subcellular Localization Toggles Its Function between Inhibiting and Promoting Axon Growth and Regeneration. *Co-corresponding author.
  Trakhtenberg, Ephraim F*; Wang, Yan; Morkin, Melina I; Fernandez, Stephanie G; Mlacker, Gregory M; Shechter, Jesse M; Liu, Xiongfei; Patel, Karan H; Lapins, Allison; Yang, Steven; Dombrowski, Susan M; and Goldberg, Jeffrey L*. The Journal of Neuroscience, 2014; 34(21):7361-74
• Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth.
  Corredor, Raul G; Trakhtenberg, Ephraim F; Pita-Thomas, Wolfgang; Jin, Xiaolu; Hu, Ying; and Goldberg, Jeffrey L. The Journal of Neuroscience, 2012; 32(22):7734-44
• Epigenetic regulation of axon and dendrite growth. *Co-corresponding author.
  Trakhtenberg, Ephraim F*; Goldberg, Jeffrey L*. Frontiers in Molecular Neuroscience, 2012; 524
• The role of serotonin in axon and dendrite growth. *Co-corresponding author.
  Trakhtenberg, Ephraim F*; Goldberg, Jeffrey L*. International Review of Neurobiology, 2012; 106105-26
• β1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival.
  Santos, Andrea Rachelle C; Corredor, Raul G; Obeso, Betty Albo; Trakhtenberg, Ephraim F; Wang, Ying; Ponmattam, Jamie; Dvoriantchikova, Galina; Ivanov, Dmitry; Shestopalov, Valery I; Goldberg, Jeffrey L; Fini, Mary Elizabeth; and Bajenaru, Michaela Livia. PloS One, 2012; 7(10):e48332
• Neuroimmune communication.
  Trakhtenberg, Ephraim F; Goldberg, Jeffrey L. Science, 2011; 334(6052):47-8
• The effects of guided imagery on the immune system: a critical review. *Corresponding author.
  Trakhtenberg, Ephraim F*. The International Journal of Neuroscience, 2008; 118(6):839-55

Books

• Axon Growth and Regeneration: Part I. Preface.
  Goldberg, Jeffrey L; Trakhtenberg, Ephraim F. (Editors. 2012). International Review of Neurobiology, 2012; 105
• Axon Growth and Regeneration: Part II. Preface.
  Goldberg, Jeffrey L; Trakhtenberg, Ephraim F. (Editors. 2012). International Review of Neurobiology, 2012; 106

Abstracts

• Link to Abstracts