Major Hereditary Cancer Syndromes

Syndrome Clinical Manifestations Gene (Percentage of Hereditary Cases)
Breast-Ovarian Cancer Syndrome Breast cancer
Ovarian cancer
Colon cancer
Prostate cancer
BRCA-1 (~45%)
BRCA-2 (~40%)
Hereditary Non-Polyposis Colon Cancer (HNPCC) Also Known as Lynch Syndrome 3 colon cancers, 2 generations Endometrial cancer
Stomach cancer
Ovarian and other cancers
MSH2 (60% ?)
MLH1 (35% ?)
PMS1 PMS2
Familial Adenomatous Polyposis (FAP) Florid colonic polyps
Colon cancer
Desmoid tumors
APC
Melanoma (Hereditary) Melanoma
Pancreatic cancer
p16 (~50%)
Multiple Endocrine Neoplasia (MEN) 2a and 2b; Familial Medullary Thyroid Cancer Medullary thyroid cancer
Parathyroid hyperplasia
Pheochromocytoma
RET