Faculty

Andrew Arnold, M.D., Professor of Medicine and Genetics and Developmental Biology, Murray-Heilig Chair in Molecular Medicine, Director, Center for Molecular Medicine. Pathogenesis of parathyroid and other endocrine tumors, and role of the cyclin D1 oncogene in neoplasia, including breast cancer.

Stefan Brocke, Associate Professor of Immunology, M.D., Freie Universistaet Berlin School of Medicine.  Cellular and molecular mechanisms of brain injury in inflammatory and inflammation-associated disorders of the central nervous system.

Ernesto Canalis,Professor of Orthopaedic Surgery and Medicine, M.D., Universidad Peruana Cayetano Heredia. The role of growth factors and their antagonists in skeletal function, such as osteoblast cell fate and function. The role of Notch and Nuclear factor of activated T cells (NFAT) in osteoblasts in vivo and in vitro, and in disease models for Hajdu Cheney Syndrome and Lateral Meningocele Syndrome.

Kevin Claffey, Professor of Cell Biology; Ph.D., Boston University School of Medicine. Angiogenesis in cancer progression and metastasis; Vascular endothelial growth factor (VEGF) expression; Hypoxia-mediated gene regulation.

Robert B. Clark, Professor of Medicine, Division of Rheumatic Diseases; M.D., Stanford. Autoimmunity and tumor immunology.

Ann Cowan, Professor of Molecular, Microbial and Structural Biology; Deputy Director, Center for Biomedical Imaging Technology; Ph.D., University of Colorado. Research encompassing several areas of mammalian sperm development.

Anne Delany, Associate Professor of Medicine. Ph.D., Dartmouth Medical School. Function and regulation of the non-collagen matrix protein osteonectin/SPARC in bone; regulation of osteoblast gene expression by microRNAs; exploring how the extracellular matrix regulates gene expression in bone-metastatic prostate carcinoma.

Kimberly Dodge-Kafka, Associate Professor of Cell Biology/Center for Cardiology and Cardiovascular Research; Ph.D., University of Texas Health Science Center-Houston. Molecular mechanism of signaling pathways in the heart.

David I. Dorsky, Associate Professor of Medicine, Division of Infectious Diseases; M.D., Ph.D., Harvard. The structure and function of herpes virus DNA polymerases and their roles in viral DNA replication.

Paul Epstein, Associate Professor of Cell Biology; Ph.D., Albert Einstein College of Medicine. Targeting the cAMP signaling pathway for treatment of leukemia and breast cancer.

Alan Fein, Professor of Cell Biology; Ph.D., Johns Hopkins. Molecular basis of visual excitation and adaptation.

J. Travis Hinson, Assistant Professor of Cardiology and Genetics, M.D., Harvard. Human iPS disease modeling of cardiovascular disorders, functional genomics, regenerative medicine related to the heart, and CRISPR/CAS9 genomewide screens in iPS-cell assays.

Guo-Hua Fong, Professor of Cell Biology, Ph.D., University of Illinois. Developmental biology of the vascular system, VEGF-A receptor signal transduction, embryonic stem cells and gene knock-out in mice.

David Han, Associate Professor, Ph.D., Washington University, 1994. Apoptosis signaling using proteomics and mass spectrometry and bioinformatics technologies.

Arthur R. Hand, Professor of Craniofacial Sciences and Cell Biology, D.D.S., University of California, Los Angeles. Study of protein and gene expression in rodent salivary glands during normal growth and development and in various experimental conditions employing morphological, immunological and biochemical methodology.

Marc Hansen, Professor of Medicine, M.S., University of Wisconsin, Ph.D. University of Cincinnati College of Medicine. Molecular genetics of osteosarcoma and related bone diseases.

Marja Hurley, Professor of Medicine, M.D., University of Connecticut School of Medicine. Molecular mechanisms by which members of the fibroblast growth factor (FGFs) and fibroblast growth factor receptor (FGFR) families, (produced by osteoblasts, osteoclasts and stromal cells) regulate bone development, remodeling and disorders of bone. Fgf2 knockout and Fgf2 transgenic mice are utilized in loss and gain of function experiments to elucidate the role of FGF-2 in disorders of bone including osteoporosis.

Laurinda A. Jaffe, Professor of Cell Biology; Ph.D., UCLA. The cell biology of fertilization, and the regulation of meiosis in oocytes.

Reinhard Laubenbacher, Professor of Cell Biology, Ph.D., Northwestern University.  Quantitative approaches to medicine, mathematical modeling of molecular and tissue processes, bioinformatics.

Eric S. Levine, Professor of Neuroscience, Ph.D., Princeton University. Synaptic physiology and plasticity, roles of nerve growth factors and endogenous cannabinoids in hippocampus and cortex.

Bruce Liang, Professor of Medicine, M.D., Harvard Medical School. Signal transduction, cardiac and vascular cell biology, receptors, G proteins, transgenic mice.

Leslie M. Loew, Professor of Cell Biology; Professor of Computer Science and Engineering; Ph.D., Cornell. Morphological determinants of cell physiology; image-based computational models of cellular biology; synapse biophysics; new optical methods for probing living cells.

Nilanjana Maulik, Professor of Surgery; Ph.D., University of Calcutta. Molecular and Cellular signaling during myocardial ischemia and reperfusion.

Lisa M. Mehlmann, Assistant Professor of Cell Biology, Ph.D., Kent State University. Signaling mechanisms that regulate meiosis.

Patrick Murphy, Assistant Professor of Cell Biology, Ph.D., University of California-San Francisco.  Unraveling the complex interplay between recruited immune cells and the endothelial lining of the vasculature in chronic inflammation, with a focus on alternative splicing and changes in the sub-endothelial matrix as critical determinants of that interaction.

Joel S. Pachter, Professor of Cell Biology; Ph.D., NYU. Elucidate the mechanisms by which leukocytes and pathogens invade the central nervous system.

John J. Peluso, Professor of Cell Biology and Obstetrics and Gynecology, Ph.D., West Virginia University. Hormonal control of ovarian follicular growth and atresia (apoptosis); characterization of a putative membrane receptor for progesterone.

Carol C. Pilbeam, Professor of Medicine; Ph.D., Yale University. M.D., Yale School of Medicine. Mechanisms of regulation of bone formation and resorption.

Vladimir Rodionov, Professor of Cell Biology; Ph.D., Moscow State University. Research in this laboratory is focused on molecular mechanisms of intracellular transport and organization of microtubule cytoskeleton.

Annabelle Rodriguez-Oquendo, Professor of Cell Biology, M.D., New Jersey Medical School. Genetic link between healthy HDL cholesterol, heart disease, and infertility in women.

Daniel W. Rosenberg, Ph.D., Professor of Medicine. Molecular genetics of colorectal cancer; signaling pathways in the development of tumors; toxicogenomics.

Archana Sanjay, Assistant Professor of Orthopaedic Surgery, School of Medicine, Ph.D.Regulation of bone remodeling; osteoblast and osteoclast differentiation and function.

Linda Shapiro, Associate Professor of Cell Biology; Ph.D., University of Michigan. Molecular mechanisms by which large cell surface peptidases regulate numerous pathologic processes ranging from angiogenesis, tumor cell invasion, chronic and acute inflammatory diseases and cardiovascular disease.

Henry Smilowitz, Associate Professor of Cell Biology, Ph.D., Massachusetts Institute of Technology. Pre-clinical experimental therapeutics of cancer using glioma, intracerebral melanoma, as well as breast, head & neck and bladder cancer models.   A.) Gold nanoparticles as radiation enhancers (with an emphasis on glioma), B.) Gold and iron nanoparticles for hyperthermia and hyperthermia mediated radiation enhancement (with an emphasis on head & neck cancer), C.) Combination of radiation therapy and immunotherapy for intracerebral tumors.

Mark R. Terasaki, Associate Professor of Cell Biology, Ph.D., University of California, Berkeley. Mechanism of nuclear envelope breakdown; structure and function of the endoplasmic reticulum.

Paola Vera-Licona, Assistant Professor of Cell Biology, Ph.D., Virginia Polytechnic Institute and State University. Computational Systems Biology of Cancer, reverse-engineering of biological networks, network theory, development and application of algorithms for mathematical modeling and analysis of biological networks, and discovery and development of combinations of targeted therapies.

Zhao-Wen Wang, Associate Professor of Neuroscience. Cellular and molecular mechanisms of neurotransmitter release; potassium and calcium channel function; Synaptic localization of potassium channels.

James Watras, Associate Professor of Cell Biology; Ph.D., Washington State. The mechanisms by which the sarcoplasmic reticulum regulates intracellular calcium concentration in vascular smooth muscle.

Bruce A. White, Professor of Cell Biology; Ph.D., Berkeley. Aspects of prolactin and growth hormone gene expression in the rat pituitary and rat pituitary tumor cell lines.

George Y. Wu, Professor of Medicine; Chief, Hepatology Section, Herman Lopata Chair in Hepatitis Research; M.D./Ph.D., Albert Einstein College of Medicine. Targeted delivery of biological substances specifically to liver cells, viral hepatitis B and C, steatohepatitis, and mitochondrial damage in liver diseases. Details of HCV replication, immunocompetent rat model of HCV infection, targeted DNA delivery, and targeted transplantation of mitochondria to hepatocytes.

Siu-Pok Yee, Assistant Professor of Genetics and Genome Sciences, PhD, MC master University. Specialties include molecular biology, mouse genetics and mouse developmental biology.

Lixia Yue, Associate Professor of Cell Biology, Center for Cardiology and Cardiovascular Biology; Ph.D., McGill University. TRP channels and Ca2+ signaling mechanisms; Physiological and pathological functions of TRP channels in heart, brain, and kidney.