This page includes a list of research studies currently supported by the CRC. Please note that some studies may not be open to enrollment. Call the study contact for more information.
Volunteers are also encouraged to visit the Information for Volunteers page for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.
For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.
Addiction/Substance Abuse | Muscle, Bone and Cartilage | Hematology/Oncology | Cardiology | Diabetes | Pulmonary | Dental Clinical Research | Infectious Disease | Psychiatry/Mental Health | Neurology | Senior Health/Aging | Women’s Health | Genetic | Other | Healthy Volunteer Studies
This page was last updated 6/20/2023
Addiction / Substance Abuse
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 51 |
089-89-1 |
Hesselbrock, Victor |
Collaborative Study on the Genetics of Alcoholism |
| 751 |
17-180H6.2 |
Mead-Morse, Erin |
Electronic Cigarette Use During Pregnancy |
| 10162 |
19-202-2 |
Mead-Morse, Erin |
Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users |
Muscle, Bone, and Cartilage
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
Hematology/Oncology
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 720 |
01-127-2 |
Machida, Kazuya |
Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies |
| 10210 |
21-167JSO-1 |
Rosenberg, Daniel |
Microbiota, Metabolites and Colon Neoplasia |
| 10211 |
U21-249-1 |
Andemariam, Biree |
An Adaptive, Randomized, Placebo-controlled, Double-blind, Multi-center Study of Oral FT-4202, a Pyruvate Kinase Agonist in Subjects with Sickle Cell Disease (PRAISE) |
| 10236 |
U22-299-2 |
Andemariam, Biree |
A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Safety and Efficacy of Inclacumab in Participants with Sickle Cell Disease Experiencing Vaso occlusive Crises |
| 10245 |
U23-049-2 |
Andemariam, Biree |
An Open-label Extension Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants with Sickle Cell Disease Who Have Participated in an Inclacumab Clinical Trial |
| 10253 |
22-327-1 |
Andemariam, Biree |
Bone Loss, Physical Function and Frailty in Older Women with Sickle Cell Trait |
Cardiology
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10220 |
22-145-2 |
Pickett, Christopher |
Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients with Heart Failure with Preserved Ejection Fraction |
| 10276 |
U24-145-1 |
Tiu, John Glenn |
A Randomized, Double-Blind, Placebo-Controlled Multicenter Study to Evaluate the Effect of Inclisiran on Preventing Major Adverse Cardiovascular Events in High-Risk Primary Prevention Patients (VICTORION-1 PREVENT) |
Diabetes
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 755 |
21-045O-1 |
Bermudez-Millan, Angela |
The Monthly Cycling of Food Insecurity and Diabetes Risk |
Pulmonary
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10045 |
12-009-2 |
Metersky, Mark |
Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions |
| 10187 |
U21-098-1 |
Metersky, Mark |
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis – The ASPEN Study |
| 10238 |
U23-047-1 |
Metersky, Mark |
A Phase 2, Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 Multi-Phage Therapeutic in Subjects with Non-Cystic Fibrosis Bronchiectasis and Chronic Pulmonary Pseudomonas Aeruginosa Infection |
| 10266 |
U24-022-1 |
Foley, Raymond |
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PROSERA) |
| 10268 |
W23-053-2 |
Metersky, Mark |
Expanded Access Protocol: Brensocatib in Patients with Non-Cystic Fibrosis Bronchiectasis |
Dental Clinical Research
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 526 |
02-288-2 |
Dongari-Bagtzoglou |
Oral Epithelial Cells, Candida and PMN Activation |
| 638 |
07-016-1 |
Freilich, Martin |
Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study |
| 680 |
09-010-1 |
Lalla, Rajesh |
Oral Mucositis Research Registry/Repository |
| 10173 |
20-045-2 |
Litt, Mark |
Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism |
| 10179 |
20-043-1 |
Chen, I-Ping |
Quantitative assessment of dental pain by measuring the electrodermal activity |
| 10218 |
U22-235-1 |
Lalla, Rajesh |
Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients (ORARAD II) |
| 10232 |
22-314-2 |
Uribe, Flavio |
A Randomized Clinical Trial Comparing the Effect of Force Magnitude on the Rate of Canine Retraction and Gingival Crevicular Fluid Proteome Profile |
Infectious Disease
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10182 |
22-232- |
Liang, Bruce |
SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients |
| 10224 |
20-186-1 |
Salazar, Juan |
Elucidation of Treponema pallidum-specific antibodies in human syphilitic serum |
Psychiatry / Mental Health
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 736 |
IE-13-048H-6.1 |
Steffens, David |
Neurobiology and Acute Treatment Outcomes of Late Life Depression |
| 10155 |
19-147-2 |
Covault, Jonathan |
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy |
| 10176 |
19-214-1 |
Manning, Kevin/ Steffens, David |
Apathy and Reward Systems in Late-Life Major Depression |
| 10194 |
O21-071-2 |
Kamath Jayesh |
A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression Protocol 54135419TRD4005 |
| 10229 |
21-143OSC-1 |
Grasso, Damion |
Impact of Perinatal Pandemic-Related Stress on the Early Caregiving Environment, Infant Functioning, DNA Methylation, and Telomere Length |
| 10242 |
W23-092-1 |
Kamath, Jayesh |
A Randomized, Double-blind, Multicenter, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants with Major Depressive Disorder (MDD) with Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy |
| 10247 |
21-257-2 |
Diniz, Breno |
The SenDep Study: Linking Molecular Senescence Changes to Depression and Cognitive impairment in Late Life |
| 10261 |
W23-227-1 |
Jain, Neha |
A Study of Disease Characteristics and Real-life Standard of Care Effectiveness in Patients with Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including an SSRI or SNRI. Protocol 67953964MDD3004 VENTURA-RWE |
| 10262 |
U23-210-2 |
Kamath, Jayesh |
A Randomized, Double-Blind, Placebo-controlled Multicenter Study to Assess the Efficacy and Safety of Lumateperone as Adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder. Protocol ITI-007-505 |
| 10263 |
W24-025-2 |
Winokur, Andrew |
A Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as an Adjunctive Treatment for Major Depressive Disorder (RELIGHT). Protocol Number: REL-1017-304 |
Neurology
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10212 |
22-122-1 |
Bulsara, Ketan |
The Intra-arterial Vasospasm Trial |
| 10223 |
n/a |
Prakash, Neha |
A Randomized Placebo-controlled Trial of Zolendronic Acid for Prevention of Fractures in Patients with Parkinson’s Disease (TOPAZ) |
| 10228 |
U22-283-2 |
Prakash, Neha |
A Double-Blind, Placebo-Controlled, Randomized, 18-Month Phase 2A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral UCB0599 in Study Participants with Early Parkinson’s Disease |
Senior Health / Aging
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
Women’s Health
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
Genetic
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 492 |
03-007-1 |
Reichenberger, Ernst |
Genetic Analysis of Human Disorders: Keloid Formation |
| 518 |
03-008-1 |
Reichenberger, Ernst |
Genetic analysis of Human disorders: Skeletal Disorders |
| 10163 |
W19-209-1 |
Riba-Wolman, Rebecca |
A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa) |
| 10217 |
U21-192-1 |
Riba-Wolman, Rebecca |
A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adeno-associated Virus Serotype 8-mediated Gene Transfer of Glucose-6-phosphatase in Patients With Glycogen Storage Disease Type Ia |
| 10219 |
U22-131-2 |
Loechner, Karen |
An Open-Label Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-3745 in Participants with Glycogen Storage Disease Type 1a (GSD1a) |
Other
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10093 |
13-132-2 |
Khan, Shakaib |
Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort |
| 10172 |
20-084-2 |
Fan, Zhichao |
Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammation |
| 10200 |
22-255-2 |
Fan, Zhichao |
Mechanisms and Roles of Integrin Activation of Cystic Fibrosis Leukocytes |
| 10221 |
22-229-1 |
Bermudez-Millan, Angela |
Barriers to WIC Farmers Market Vouchers Redemption among Hartford WIC Participants:
A Community-Based Pilot Study to Strengthen WIC Benefits Use and to Develop a Childhood Obesity Intervention |
| 10222 |
22-174-2 |
Fan, Zhichao |
Investigating Mechanisms and Roles of Integrin Activation of Human Blood Leukocytes in Mitofusin (MFN2) Disease Condition; Charcot-Marie-Tooth Neuropathy (CMT2A) |
| 10233 |
22-320J-2 |
Ucar, Duygu |
Next-Generation Sequencing Analysis of Healthy Human Cells |
| 10255 |
W24-031-2 |
Rezaizadeh, Houman |
A Phase 2/3, Randomized, 3-Part Study to Investigate the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients with Eosinophilic Gastritis with or without Eosinophilic Duodenitis (The “Engage” Study) |
| 10264 |
24-023J-2 |
Robson, Paul |
An open resource of human induced pluripotent stem cells lines from diverse population groups. |
Healthy Volunteer Studies
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10254 |
23-193J-1 |
Wang, Eric |
Healthy Control Blood Collection to Investigate Mechanisms of Therapy Resistance in Hematologic Malignancies |
| 10265 |
N/A |
Adams, Mark |
Collection of Human Specimens for Validation of Assays in the JAX Advanced Precision Medicine Lab (This is a non-research study) |