Our Research
Established in 1986, the Center on Aging supports a robust, nationally recognized research program focused on preventing or minimizing disability and promoting quality of life in aging adults. Our interdisciplinary and translational research develops a mechanistic understanding of disability, generates and tests innovative interventions, and trains future academic leaders in geriatrics and gerontology. Our research studies seek to develop more precise and individualized ways of maintaining function in late life by preventing mobility problems, fractures, pneumonia, and voiding and memory difficulties.
Our faculty conduct world-class research to improve function and independence in late life, supported by a research portfolio of more than $5 million per scientist. Their research skills include clinical, translational, basic, and health outcomes/population research. This diversity allows the Center on Aging to continually enhance its research activities by monitoring the scientific progress of many relevant research disciplines and translating those discoveries from one discipline (e.g., basic research) to another (e.g., clinical investigation). We also work to translate discoveries made at academic institutions by validating them in “real world” community settings.
Research studies conducted at the UConn Center on Aging are designed to:
- Foster a better understanding of the pathophysiological mechanisms by which inflammatory and endocrine risk factors contribute to frailty and disability.
- Conduct preclinical and clinical trials intended to prevent or delay frailty and disability.
- Better understand how frailty and disability are associated with sociocultural and behavioral factors, as well as healthcare and long-term care service delivery and costs.
Be A Part of Our Healthy Aging Initiatives
To join our mailing list to learn about UConn Center on Aging, Pepper Center events and research study opportunities, Call: (860) 679-3043, Email: Lisa Pesce: Kenyon-pesce@uchc.edu, click this link: https://dev-redcap.uchc.edu/redcap/surveys/?s=TWY77PRPHTN8LK8X or scan the QR code below:
UConn Claude D. Pepper Older Americans Independence Center Recruitment Volunteer Registry, IRB# 23-134-2
Active Research Studies at the Center on Aging
Apathy and Reward Systems in Alzheimer's Disease
This research is being done to better understand apathy, also known as loss of interest. Apathy can occur in depression and in Alzheimer’s disease, but we do not know if how apathy presents in depression and Alzheimer’s is similar or how it affects brain circuits. This study will look at how apathy presents in depression and Alzheimer’s disease and will identify brain changes related to apathy in these two groups.
The study is currently recruiting adults 65 - 85 years old who are diagnosed with depression. To learn more or see if you are eligible to participate, please call Suzy Crumb at 860-679-8497 or email crumb@uchc.edu.
Principal Investigator
| David Steffens, M.D., M.H.S. | |
| Professor and Chair, Department of Psychiatry | |
| steffens@uconn.edu | |
Study Coordinator
| Jennifer Brindisi | |
| Clinical Research Assistant III | |
| brindisi@uchc.edu |
Apathy: An Early Manifestation of Frailty and Disability in Older Adults with Depression?
Older adults lost almost $1.7 billion in financial scams in 2021. Better understanding of financial decision making in older adults is necessary in order to help older adults avoid fraud. The purpose of this research is to understand the cognitive, emotional, and motivational components of financial decision making in older adults. The study staff is recruiting men and women age 60+ with or without depression.
Principal Investigator
| Kevin Manning, PhD | |
| Associate Professor | |
| manning@uchc.edu | |
Study Coordinator
| Kara Dion | |
| Clinical Research Assistant | |
| kdion@uchc.edu |
Biomarker Development to Promote Geroscience-Guided Approaches to Chronic Lower Limb Wound Management in Older Adults
The purpose of this study is to understand the reason why, in older adults, certain wounds heal rapidly while other wounds have difficulty healing. Study investigators follow the individual throughout their wound healing process. This study observes wound progression to obtain wound punch biopsies, microbiology swabbing, blood and urine samples at various points of wound healing, with no intervention or disruption in the individual’s standard treatment of care.
Principal Investigator
| Roshanak Sharafieh, PhD | |
| Assistant Professor | |
| rsharafieh@uchc.edu | |
Study Coordinator
| Heather McAbee-Sevick, RN | |
| Clinical Research Associate | |
| mcabeesevick@uchc.edu |
Cognitive Remediation of Cognitive Control in Late-Life Depression
This research is being done to determine if computerized brain-training treatment will improve thinking and depression in older depressed adults who are being treated with antidepressants. We are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance imaging (MRI). Participants will be randomly assigned to one of two different interventions.
The study is currently recruiting adults 60 years of age or older who are experiencing an episode of mild or major depression and have been taking an antidepressant medication for at least 8 weeks. To learn more or see if you are eligible to participate, please call Katie Boyle at 860-679-6189 or email kboyle@uchc.edu.
Principal Investigators
| Kevin Manning, PhD | |
| Associate Professor | |
| manning@uchc.edu | |
Study Coordinators
| Jennifer Brindisi | |
| Clinical Research Assistant III | |
| brindisi@uchc.edu |
Cognitive Remediation of Executive Deficits in Geriatric Depression
The purpose of this study is to test how well depressed older adults are able to complete a computerized program (Neuroflex) designed to improve certain types of “thinking” skills and whether participating in Neuroflex will improve both cognition and mood. This research is being done because usual antidepressants may not be fully effective and/or may be associated with cognitive deficits in many older adults with depression. This leaves them vulnerable to future depressive episodes. The development of new, non-invasive treatments that may help both mood and cognitive symptoms could potentially help older adults with depression.
The study is currently recruiting adults 55 and older who have symptoms of depression and have not been diagnosed with dementia or mild cognitive impairment. To learn more or see if you are eligible to participate, please call Frances Jaynes at 860-679-7948 or email jaynes@uchc.edu.
Principal Investigators
| David Steffens, M.D., M.H.S. | |
| Professor and Chair, Department of Psychiatry | |
| steffens@uconn.edu | |
Study Coordinators
| Jennifer Brindisi | |
| Clinical Research Assistant III | |
| brindisi@uchc.edu |
Community Services Care Plan Study
The purpose of the study, funded by the National Institute on Aging, is to understand how well goals of care are addressed and to compare the experiences of participants in the Connecticut Home Care Program for Elders.
Study team members are recruiting CHCPE enrollees to participate in a one-on-one interview about their goals of care.
For questions, please email Kate Kellett at kkellett@uchc.edu
Principal Investigators
| Rick Fortinsky | Julie Robison, PhD |
| Professor | Professor |
| fortinsky@uchc.edu | jrobison@uchc.edu |
Study Coordinators
| Kate Kellett | Deb Migneault |
| Clinical Research Associate | Clinical Research Associate |
| kkellett@uchc.edu | demigneault@uchc.edu |
CoreQ Nursing Home Satisfaction Survey
The Connecticut Department of Social Services (DSS) has contracted with the UConn Center on Aging to collect annual satisfaction surveys, called the CoreQ, from residents and family members in every Medicaid-certified nursing home in Connecticut. CT DSS will incorporate nursing home quality into Medicaid payment rates and the results of the CoreQ survey will be a part of determining these rates.
Study team members from UConn Center on Aging will annually visit each Medicaid-certified nursing home in the state and administer the CoreQ survey to a sample of eligible nursing home residents. Additionally, a sample of nursing home resident family members or resident representatives will be surveyed.
Click here to learn more about the CoreQ
For questions, please email: uconnnursinghomesurvey@uchc.edu
Click here for Feb. 1, 2024 Connecticut Nursing Home CoreQ overview webinar slides
Click here for FAQs about the CoreQ survey administration process
Principal Investigators
| Ellis Dillon, PhD | Julie Robison, PhD |
| Assistant Professor | Professor |
| edillon@uchc.edu | jrobison@uchc.edu |
Study Coordinators
| Sarah Driscoll | Deb Migneault |
| Clinical Research Assistant 2 | Clinical Research Associate 2 |
| sdriscoll@uchc.edu | demigneault@uchc.edu |
Department of Developmental Services: National Core Indicator (NCI) Survey
The UConn Center on Aging study team is contracted with the Connecticut Department of Developmental Services to conduct the annual National Core Indicator Survey. The survey is designed to provide DDS with DDS participants’ feedback on their experiences receiving supports from the Department of Developmental Services and living their lives in the community.
For questions, please email: dcharles@uchc.edu
Principal Investigator
| Ellis Dillon, PhD | |
| Assistant Professor | |
| edillon@uchc.edu | |
Study Coordinator
| Doreek Charles | |
| Clinical Research Associate | |
| dcharles@uchc.edu |
Hematopoietic Epigenetic Memory as a Driver of Inflammation
This new study is designed to help better understand how aging remodels the immune cells in the blood and affects the response to vaccines in older individuals. Participating does not include receiving a vaccination, but rather studying the immune system as we age. Participants who enroll will come for a single study visit where medical history and physical activity questionnaires are done and a blood sample collected. Participants must be between the ages of 20-35 or 65 years old and older. Participant compensation is provided.
Interested in learning more? (860) 679-3043
Principal Investigator
| George Kuchel, MD | |
| Professor | |
| kuchel@uchc.edu | |
Study Coordinator
| Allison Laska | |
| Clinical Research Assistant | |
| alaska@uchc.edu |
Increasing successful returns to community living from nursing facilities through the Money Follows the Person program
Most people living with dementia (PLWD) prefer to remain at home in the community, yet research shows that they are less likely than people without dementia to successfully return to the community following nursing facility stays. This mixed methods study, funded by the National Institute on Aging, analyzes how different factors are driving disparities for PLWD and what potential policy solutions could improve health equity for PLWD, through in-depth interviews with individuals eligible for the Money Follows the Person (MFP) program and their informal caregivers, focus groups and surveys with professionals involved in the MFP program, and statistical analysis of a large group of Connecticut Medicaid nursing facility residents.
Study team members are interviewing eligible participants and caregivers for one-on-one interviews about returning to the community after a nursing home stay. Study team members are also conducting focus groups and key informant interviews with professionals in the MFP program.
For questions, please email Christine Bailey at cbailey@uchc.edu
Principal Investigators
| Ellis Dillon, PhD | Julie Robison, PhD |
| Assistant Professor | Professor |
| edillon@uchc.edu | jrobison@uchc.edu |
Study Coordinators
| Christine Bailey | Deb Migneault | Kate Kellett |
| Clinical Research Assistant 3 | Clinical Research Associate | Clinical Research Associate |
| cbailey@uchc.edu | demigneault@uchc.edu | kkellet@uchc.edu |
Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
The research is being done to determine whether a antioxidant vitamin called MitoQ improves blood flow, physical health and strength, and mental abilities of older adults.
Call the UConn Center on Aging , 860-679-3043 to learn more.
Principal Investigator
| Oh Sung Kwon, PhD |
| Assistant Professor |
| ohsung.kwon@uconn.edu |
Study Coordinator
| Sarah Driscoll | |
| Clinical Research Assistant | |
| sdriscoll@uchc.edu |
Mito-LUTS: A Pilot Study of the Effect of MitoQ on Lower Urinary Tract Symptoms in Older Women with Metabolic Syndrome
Lower urinary tract symptoms (LUTS) have a high incidence, with well-documented negative effects on the quality of life of affected individuals. This study will look to see if a supplement, MitoQ, can improve bothersome bladder symptoms (including urgency, frequency, nocturia, and incontinence) that can occur with aging and metabolic syndrome.
Principal Investigator
| Iman M. Al-Naggar, PhD |
| Assistant Professor |
| alnaggar@uchc.edu |
Study Coordinator
| Heather McAbee-Sevick, RN | |
| Clinical Research Associate | |
| mcabeesevick@uchc.edu |
Money Follows the Person Home and Community Based Services (HCBS) CAHPS Survey
As part of the comprehensive Money Follows the Person program (MFP) quality management strategy, the UConn Center on Aging study team directly interviews participants or their representatives asking about their experiences in the year after transition through the MFP program. MFP consumers are interviewed at 1 month and 12 months post-transition to identify the quality of care and services each consumer experiences over the entirety of their time in the MFP program using the Consumer Assessment of Healthcare Providers and Systems Home and Community-Based Services (HCBS CAHPS®) survey.
Principal Investigator
| Julie Robison, PhD |
| Professor |
| jrobison@uchc.edu |
Study Coordinators
| Martha Porter | Therence James |
| Clinical Research Associate | Clinical Research Assistant |
| porter@uchc.edu | tjames@uchc.edu |
Peer Coaching to Improve Physical Activity in Older Latinx Adults with Parkinson’s Disease
This research study is examining whether peer-supported mobile health exercise in Hispanic/Latino/Latinx people with Parkinson’s Disease will be beneficial to physical health, improve disease management and help find a better way to maintain and prevent the disease progressing.
Principal Investigator
| Cristina Colon-Semenza, PhD |
| Assistant Professor |
| cristina.colon-semenza@uconn.edu |
Study Coordinators
| Jovany Figueroa Amara | |
| Clinical Research Assistant | |
| figueroaamaro@uchc.edu |
Phenotype Predictors of Cognitive Outcomes in Geriatric Depression
This research is being done to understand the effects of stress on mood, cognition, and response to treatment of depression in older adults and to examine stress effects on brain structure and function in late-life depression (LLD). Understanding how effects of stress in older depressed adults lead to particular mood and cognitive outcomes will inform future development of new prevention strategies.
The study is currently recruiting adults 60 and older who are experiencing symptoms of depression. To learn more or see if you are eligible to participate, please call 860-679-7571 or email Judy Anderson at judanderson@uchc.edu.
Principal Investigator
| David Steffens, M.D., M.H.S. |
| Professor and Chair, Department of Psychiatry |
| steffens@uconn.edu |
Study Coordinators
| Jennifer Brindisi | |
| Clinical Research Assistant III | |
| brindisi@uchc.edu |